Clinical Trial | By G Tarantini , M Mojoli , F Varbella et al.
BACKGROUND - Although oral P2Y12 inhibitors are key in the management of patients with non–ST-segment elevation acute coronary syndrome, the optimal timing of their administration is not well defined. OBJECTIVES - The purpose of this study was to compare downstream and upstream oral P2Y12 inhibitors administration strategies in patients with non–ST-segment elevation acute coronary syndrome undergoing invasive...
Association of Left Ventricular Systolic Function With Incident Heart Failure in Late Life
Original Research | By AMR Jensen, R Zierath, B Claggett et al.
IMPORTANCE - Limited data exist regarding the association of subtle subclinical systolic dysfunction and incident heart failure (HF) in late life. OBJECTIVE - To assess the independent associations of subclinical impairments in systolic performance with incident HF in late life. DESIGN, SETTING, AND PARTICIPANTS - This study was a time-to-event analysis of parti...
Original Research | By F Bedogni; AP Rubbio; C Grasso et al.
AIMS - The Italian Society of Interventional Cardiology (GIse) Registry Of Transcatheter Treatment of Mitral Valve RegurgitaTiOn (GIOTTO) was conceived in order to assess the safety and efficacy of the MitraClip therapy in Italy. Aim of the study was to assess the procedural, the mid-term outcomes and their predictors after MitraClip therapy, stratifying the results according to diagnosis of functional and degenerative mitr...
Original Research | By F Bedogni; AP Rubbio; C Grasso et al.
AIMS - The Italian Society of Interventional Cardiology (GIse) Registry Of Transcatheter Treatment of Mitral Valve RegurgitaTiOn (GIOTTO) was conceived in order to assess the safety and efficacy of the MitraClip therapy in Italy. Aim of the study was to assess the procedural, the mid-term outcomes and their predictors after MitraClip therapy, stratifying the results according to diagnosis of functional and degenerative mitr...
Original Research | By D del Val, M Abdel-Wahab, J Rodés-Cabau et al.
BACKGROUND - Procedural improvements combined with the contemporary clinical profile of patients undergoing transcatheter aortic valve replacement (TAVR) may have influenced the incidence and outcomes of infective endocarditis (IE) following TAVR. We aimed to determine the temporal trends, characteristics, and outcomes of IE post-TAVR. METHODS - Observational study including 552 patients prese...
Original Research | By B Bozkurt, RE Hershberger, J Butler et al.
Selection of stenting approach for coronary bifurcation lesions
Coronary bifurcation lesions are a challenging lesion subset of coronary artery obstructive diseases. With the rapid development of stent platforms, drug-coating techniques, a new generation of antiplatelet therapeutic drugs, intravascular imaging, and a better understanding of the abnormal flow dynamics around bifurcated areas, patients after stenting of coronary bifurcation lesions have shown a dramatic reduction in major adverse cardiac events (M...
Original Research | By WP Liu, PF Guo, T Dai
Comprehensive understanding of plasma metabotype of diabetes mellitus (DM), coronary heart disease (CHD), and especially diabetes mellitus with coronary heart disease (CHDDM) is still lacking. In this work, the plasma metabolic differences and links of DM, CHD, and CHDDM patients were investigated by the strategy of comparative metabolomics based on 1H NMR spectroscopy combined with network analysis for revealing their m...