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Management of Acute Myocardial Infarction During the COVID-19 Pandemic
CSC Expert Consensus on Principles of Clinical Management of Patients with Severe Emergent Cardiovascular Diseases during the COVID-19 Epidemic
ACC临床简报:新型冠状病毒对心脏的影响(2019-nCoV)
SCAI Expert Consensus Statement Update on Best Practices for Transradial Angiography and Intervention
Left Main Bifurcation Angioplasty: Are 2 Stents One Too Many?
Please click on the "Article Link" to read the article content.
Clinical Trial | By Ahn JM, Roh JH, Park SJ et al.
BACKGROUND - In a previous randomized trial, we found that percutaneous coronary intervention (PCI) was not inferior to coronary artery bypass grafting (CABG) for the treatment of unprotected left main coronary artery stenosis at 1 year. OBJECTIVES - This study sought to determine the 5-year outcomes of PCI compared with CABG for the treatment of unprotected left main coronary artery stenosis. ...
Clinical Trial | By Ferreira de Souza T, Quinaglia A C Silva T, Coelho-Filho OR et al.
OBJECTIVES - The goal of this study was to demonstrate that cardiac magnetic resonance could reveal anthracycline-induced early tissue remodeling and its relation to cardiac dysfunction and left ventricular (LV) atrophy. BACKGROUND - Serum biomarkers of cardiac dysfunction, although elevated after chemotherapy, lack specificity for the mechanism of myocardial tissue alterations. METHO...
Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation
Original Research | By Zhang JX, Qu XL, Chen SL et al.
Uncoupled endothelial nitric oxide synthase (eNOS) produces O2- instead of nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O2- production. Nevertheless, it is unclear whether autophagy plays a critical role in the regulation of eNOS uncoupling. Therefore, this study aimed to investigate the modulation of autophagy on eNOS uncoupling in...
Low shear stress induces endothelial reactive oxygen species via the AT1R/eNOS/NO pathway
Original Research | By Chao Y, Ye P, Chen SL et al.
Reactive oxygen species (ROS) contribute to many aspects of physiological and pathological cardiovascular processes. However, the underlying mechanism of ROS induction by low shear stress (LSS) remains unclear. Accumulating evidence has shown that the angiotensin II type 1 receptor (AT1R) is involved in inflammation, apoptosis, and ROS production. Our aim was to explore the role of AT1R in LSS-mediated ROS induction. We ex...
Original Research | By Gamou T, Sataka K，Yamagishi M et al.
OBJECTIVES - To investigate the impact of stent deformity induced by final kissing balloon technique (KBT) for coronary bifurcation lesions on in-stent restenosis (ISR). BACKGROUND - In experimental models, the detrimental effects of KBT have been clearly demonstrated, but few data exists regarding the impact of proximal stent deformity induced by KBT on clinical outcomes. ...
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
Original Research | By The ASCEND Study Collaborative Group.
BACKGROUND - Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. METHODS - We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive ...
Review Article | By Antithrombotic Trialists’ (ATT) Collaboration.
Novel developments in revascularization for left main coronary artery disease
Editorial | By Carreras ET, Bhatt DL.
Please click on the "Article Link" on the right to get access to this article. Quotation "When PCI is used to treat LM bifurcation lesions, DK-CRUSH is the most reasonable evidence-based approach."
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