Original Research | By A Khera , MJ Budoff , CJ O’Donnell et al.
BACKGROUND - Coronary artery calcium (CAC) is a powerful novel risk indicator for atherosclerotic cardiovascular disease (ASCVD). Currently, there is no available ASCVD risk prediction tool that integrates traditional risk factors and CAC. METHODS - To develop a CAC ASCVD risk tool for younger individuals in the general population, subjects aged 40-65 without prior CVD from three population-based...
Clinical Trial | By McClelland RL, Jorgensen NW, Budoff M et al.
BACKGROUND - Several studies have demonstrated the tremendous potential of using coronary artery calcium (CAC) in addition to traditional risk factors for coronary heart disease (CHD) risk prediction. However, to date, no risk score incorporating CAC has been developed. OBJECTIVES - The goal of this study was to derive and validate a novel risk score to estimate 10-year CHD risk using CAC and traditio...
Original Research | By JM Lee, KH Choi, D Hwang et al.
OBJECTIVES - This study investigated the prognostic implication of coronary flow reserve (CFR) in patients who underwent fractional flow reserve (FFR) measurement. BACKGROUND - Limited data are available regarding the long-term prognosis associated with thermodilution CFR in patients with coronary artery disease. METHODS - A total of 519 patients (737 vessels) who did not undergo re...
Recommandation Statement | By US Preventive Services Task Force
Screening for Atrial Fibrillation With ECG: USPSTF Recommendation
Clinical Trial | By K Hibi, K Kozuma, S Sonoda et al.
OBJECTIVES - The aim of this study was to evaluate the utility of distal protection during percutaneous coronary intervention (PCI) in patients with acute coronary syndromes at high risk for distal embolization. BACKGROUND - The results of previous clinical trials indicated that the routine use of distal protection in patients with ST-segment elevation myocardial infarction did not improve clinical outcomes. Howe...
Original Research | By Javier Escaned, Nicola Ryan, Hernán Mejía-Rentería
OBJECTIVES - The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND - Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the ...
Original Research | By D Nakamura, W Wijns, MJ Price et al.
OBJECTIVES - This study sought to compare conventional methodology (CM) with a newly described optical coherence tomography (OCT)-derived volumetric stent expansion analysis in terms of fractional flow reserve (FFR)-derived physiology and device-oriented composite endpoints (DoCE). BACKGROUND - The analysis of coronary stent expansion with intracoronary imaging has used CM that relies on the analysis o...
Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction
Original Research | By Y Wang, J Li, LX Jiang et al.
IMPORTANCE - Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify risk factors for recurrence have primarily focused on the period immediately following AMI admission. OBJECTIVES - To identify risk factors and develop and evaluate a risk model that predicts 1-year cardiovascular events after AMI. DESIGN, SETTI...
Original Research | By MJ Yang, L Song, L Wang et al.
BACKGROUND - Macrophages are highly plastic cells that play an important role in the pathogenesis of cardiovascular disease. OBJECTIVES - This study investigated the role of GATA3-positive macrophages in modulating cardiac function after myocardial infarction (MI) or in response to pressure overload hypertrophy. METHODS - Myeloid-specific GAT...