Clinical Trial | By Lee BK, Kim JS, Lee OH et al.
AIMS - There are few randomised studies concerning the optimal duration of dual antiplatelet therapy (DAPT) for patients who receive a second-generation drug-eluting stent (DES). This trial aimed to investigate the safety of six-month compared with 12-month DAPT maintenance after second-generation DES implantation. METHODS AND RESULTS - A prospective, randomised, multicentre trial w...
Clinical Trial | By M Brodmann, M Werner, the ILLUMENATE EU RCT Investigators.
OBJECTIVES - The aim of this study was to assess the safety and effectiveness of a next-generation low-dose drug-coated balloon (DCB) designed to optimize the amount of drug transferred into the vessel wall and to maximize the amount of time the drug resides in the vessel wall. BACKGROUND - Several randomized controlled studies evaluating various DCBs have demonstrated a significantly higher patency...
Clinical Trial | By YD Chen, L Gao, Q Qin et al.
OBJECTIVES - The aim of the present study was to evaluate the angiographic efficacy, clinical safety, and effectiveness of the Restore paclitaxel-coated balloon in a randomized trial designed to enable the approval of the new device in China. BACKGROUND - Drug-coated balloon (DCB) angioplasty offers an effective treatment for in-stent restenosis. Restore is a new DCB with a SAFEPAX shellac-amm...
Original Research | By Uskela S, Kärkkäinen JM, Eränen J et al.
OBJECTIVES - The aim of this single center all-comers retrospective registry study was to assess the efficacy and safety of percutaneous coronary intervention (PCI) using drug-coated balloon (DCB) in de novo lesions including large proximal coronary arteries. METHODS - A total of 487 PCIs were performed using paclitaxel-coated DCB in 562 de novo lesions with the possibility for bailout stenting in a pati...
Clinical Trial | By Kosmala W, Przewlocka-Kosmala M, Marwick TH et al.
OBJECTIVES - This study sought to determine the prognostic value of abnormal diastolic and systolic responses to exercise (on the basis of exertional E/e' and global longitudinal strain rate [GSR]) in a well-characterized population of patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND - Impaired cardiovascular functional reserve is believed to contribute to adverse out...
Clinical Trial | By Zacharias M1, Joffe S, Goldberg RJ et al.
Heart Failure With Preserved Ejection Fraction in the Young
Original Research | By J Tromp , MR MacDonald, CSP Lam et al.
Original Research | By RP Amier, MW Smulders, R Nijveldt et al.