Canadian SCAD Cohort Study: Shedding Light on SCAD From a United Front
Expert Opinion | By Calvin Ka Wing Tong, MD; Dr. Jacqueline W. L. Saw, MD, FACC
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI), particularly affecting young women. It is defined as a non-traumatic, non-iatrogenic, and non-atherosclerotic separation of the coronary arterial wall by intramural hematoma, resulting in a false lumen with or without intimal tear. Intramural hematoma can accumulate between any arterial layer (intima, media, or adventitia) an...
Original Research | By F Alqahtani, KM Ziada, V Badhwar et al.
BACKGROUND - Post-operative acute coronary ischemia is an uncommon complication of coronary artery bypass grafting (CABG). However, data on the incidence and outcomes of early coronary ischemia and in-hospital percutaneous coronary interventions (PCIs) after CABG are scarce. OBJECTIVES - The aim of this study was to assess the incidence, predictors, and outcomes of early (in-hospital) PCI following C...
Original Research | By van Rein N, Heide-Jørgensen U, Lijfering WM et al.
Original Research | By Lim CC, Hayes RB, Ahn J et al.
BACKGROUND - Recent experimental evidence suggests that nutritional supplementation can blunt adverse cardiopulmonary effects induced by acute air pollution exposure. However, whether usual individual dietary patterns can modify the association between long-term air pollution exposure and health outcomes have not been previously investigated. We assessed, in a large cohort with detailed diet information at the individual level, whethe...
Original Research | By Fracassi F, Niccoli G, Vetrugno V et al.
BACKGROUND - Patients with acute coronary syndrome (ACS) associated to high C-reactive protein (CRP) levels exhibit a higher risk of future acute ischemic events. Yet, the positive predictive value of CRP is too low to guide a specific treatment. Our study aims to identify a high-risk patient subset who might mostly benefit from anti-inflammatory treatment on the basis of the combination of optical coherence tomography ...
Original Research | By Farkouh ME, Domanski M, FREEDOM Follow-On study investigators.
BACKGROUND - The FREEDOM trial demonstrated that for patients with diabetes mellitus (DM) and multivessel coronary disease (MVD), coronary artery bypass grafting (CABG) is superior to percutaneous coronary intervention with drug-eluting stents (PCI-DES) in reducing the rate of major adverse cardiovascular and cerebrovascular events after a median follow-up of 3.8 years. It is not known, however, whether CABG con...
Circadian-Regulated Cell Death in Cardiovascular Diseases
Original Research | By Rabinovich-Nikitin I, Lieberman B, Martino TA et al.
Original Research | By Fanaroff AC, Clare R, Pieper KS et al.
Classification of Deaths in Cardiovascular Outcomes Trials Known Unknowns and Unknown Unknowns