The Future of Cardiovascular Computed Tomography Advanced Analytics and Clinical Insights
Review Article | By ED Nicol, BL Norgaard, P Blanke et al.
Cardiovascular computed tomography (CCT) has undergone rapid maturation over the last decade and is now of proven clinical utility in the diagnosis and management of coronary artery disease, in guiding structural heart disease intervention, and in the diagnosis and treatment of congenital heart disease. The next decade will undoubtedly witness further advances in hardware and advanced analytics that will potentially see an increa...
Clinical Trial | By T Hirai, M Qintar, on behalf of the OPEN CTO Study Group et al.
BACKGROUND - Prior research has shown that providers may infrequently adjust antianginal medications (AAMs) following chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Patient characteristics associated with AAM titration and the variation in postprocedure AAM management after CTO PCI across hospitals have not been reported. We sought to determine the frequency and potential correlates of AAM escala...
Original Research | By Qintar M, Hirai T, Salisbury AC et al.
BACKGROUND - Successful chronic total occlusion (CTO) percutaneous coronary intervention (PCI) can markedly reduce angina symptom burden, but many patients often remain on multiple antianginal medications (AAMs) after the procedure. It is unclear when, or if, AAMs can be de-escalated to prevent adverse effects or limit polypharmacy. We examined the association of de-escalation of AAMs after CTO PCI with long-term h...
Original Research | By Valle JA,, Glorioso TJ, Bricker R et al.
IMPORTANCE - Anatomical scoring systems for coronary artery disease, such as the SYNTAX (Synergy Between Percutaneous Coronary Intervention [PCI] With Taxus and Cardiac Surgery) score, are well established tools for understanding patient risk. However, they are cumbersome to compute manually for large data sets, limiting their use across broad and varied cohorts. OBJECTIVE - To adapt an anato...
Negative Risk Markers for Cardiovascular Events in the Elderly
Original Research | By MB Mortensen, V Fuster, P Muntendam et al.
BACKGROUND- Cardiovascular risk increases dramatically with age, leading to nearly universal risk-based statin eligibility in the elderly population. To limit overtreatment, elderly individuals at truly low risk need to be identified. OBJECTIVES- Discovering “negative” risk markers able to identify elderly individuals at low short-term risk for coronary heart disease and cardiovascular disease. ...
Original Research | By Duffels MG, Engelfriet PM, Berger RM et al.
BACKGROUND - Pulmonary arterial hypertension (PAH) associated with congenital heart disease is usually the result of a large systemic-to-pulmonary shunt, and often leads to right ventricular failure and early death. The purpose of this study was to determine the prevalence of PAH among adult patients included in a national registry of congenital heart disease and to assess the relation between patient characteristics and PAH. ...
Review Article | By Diller GP, Kempny A, Inuzuka R et al.
OBJECTIVES - To investigate survival in patients with Eisenmenger syndrome based on a systematic review of the literature and reanalysis of data. We specifically tested the hypothesis that previous publications have been subject to immortal time bias, confounding survival analyses. METHODS - A systematic review of the literature was performed to evaluate survival in treatment naïve patients with Eisenmenger sy...
Original Research | By van Riel AC, Schuuring MJ, Bouma BJ et al.
BACKGROUND - The aging congenital heart disease (CHD) population is prone to develop a variety of sequelae, including pulmonary arterial hypertension (PAH). Previous prevalence estimates are limited in applicability due to the use of tertiary centers, or database encoding only. We aimed to investigate the contemporary prevalence of PAH in adult CHD patients, using a nationwide population. METHODS&nbs...
Pulmonary hypertension related to congenital heart disease: a call for action