科学研究 - The Left Main and Coronary Artery Bifurcation Lesion Summit (CBS)

Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review

Review Article | By L Cho, M Davis, and for the ACC CVD Womens Committee Members.

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for women in the United States and worldwide. There has been no American College of Cardiology (ACC)/American Heart Association guideline update specifically for the prevention of CVD in women since 2011. Since then, the body of sex-specific data has grown, in addition to updated hypertension, cholesterol, diabetes, atrial fibrillation, and primary...

Transcatheter Aortic Valve Replacement During Pregnancy

Clinical Case Study | By R Hodson, E Kirker, J Swanson et al.

Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association

| By LS Mehta , CA Warnes, and On behalf of the American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Stroke Council

Subcutaneous Selatogrel Inhibits Platelet Aggregation in Patients With Acute Myocardial Infarction

Original Research | By P Sinnaeve, G Fahrni, M Valgimigli et al.

BACKGROUND - Oral P2Y12 receptor antagonists exhibit delayed onset of platelet inhibition in patients with acute myocardial infarction (AMI). Selatogrel is a potent, highly selective, and reversible P2Y12 receptor antagonist with a rapid onset and short duration of action. OBJECTIVES - This study sought to assess inhibition of platelet aggregation following subcutaneous administration of selatogre...

Evaluation and Management of Nonculprit Lesions in STEMI

Original Research | By T Thim, NW van der Hoeven, C Musto et al.

Nonculprit lesions are frequently observed in patients with ST-segment elevation myocardial infarction. Results from recent randomized clinical trials suggest that complete revascularization after ST-segment elevation myocardial infarction improves outcomes. In this state-of-the-art paper, the authors review these trials and consider how best to determine which nonculprit lesions require revascularization and when this should be performed....

Multivessel Versus Culprit-Vessel Percutaneous Coronary Intervention in Cardiogenic Shock

Original Research | By A Lemor, MB Basir, and on behalf of the National Cardiogenic Shock Initiative Investigators.

OBJECTIVES - This study sought to compare outcomes of patients enrolled in the NCSI (National Cardiogenic Shock Initiative) trial who were treated using a revascularization strategy of percutaneous coronary intervention (PCI) of multivessel PCI (MV-PCI) versus culprit-vessel PCI (CV-PCI). BACKGROUND - In patients with multivessel disease who present with acute myocardial ...

Comparative effectiveness analysis of percutaneous coronary intervention versus coronary artery bypass grafting in patients with chronic kidney disease and unprotected left main coronary artery disease

Original Research | By DW Kim, SY Om, MW Park et al.

AIMS - Outcomes according to the status of renal insufficiency have not been fully evaluated in left main coronary artery disease (LMCAD). In the present study therefore, we sought to evaluate clinical outcomes in patients with significant LMCAD stratified by the degree of renal insufficiency and the relative clinical outcomes after PCI and CABG stratified by the differential levels of renal function using data from the large multina...

Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease: JACC State-of-the-Art Review

Review Article | By V Narayan, EW Thompson, B Demissei et al.

Cardiovascular disease (CVD) and cancer are leading causes of morbidity and mortality worldwide. Although conventionally managed as separate disease processes, recent research has lent insight into compelling commonalities between CVD and cancer, including shared mechanisms for disease development and progression. In this review, the authors discuss several pathophysiological processes common to both CVD and cancer, such as inflammat...

Drug-Coated Balloon Angioplasty Versus Drug-Eluting Stent Implantation in Patients With Coronary Stent Restenosis

Original Research | By D Giacoppo, F Alfonso, B Xu et al.

Prognostic Value of SYNTAX Score in Patients With Infarct-Related Cardiogenic Shock: Insights From the CULPRIT-SHOCK Trial

Original Research | By P Guedeney, O Barthélémy, M Zeitouni et al. cardiogenic shockpercutaneous coronary interventionSYNTAX score

OBJECTIVES - This study sought to evaluate the prognostic value of the SYNTAX (SYNergy between PCI with TAXUS and Cardiac Surgery) scores in patients undergoing percutaneous coronary intervention (PCI) for multivessel coronary disease with infarct-related cardiogenic shock (CS). BACKGROUND - The prognostic value of the SYNTAX score in this high-risk setting remains unclear. &...