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Dual Antiplatelet Therapy Duration in Medically Managed Acute Coronary Syndrome Patients: Sub-Analysis of the OPT-CAD Study

Original Research | By Sicong Ma, Zaixin Jiang, YL Han et al.

INTRODUCTION - Optimal dual antiplatelet therapy (DAPT) duration for medically managed acute coronary syndrome (ACS) (MMACS) patients is still unknown. We explored the efficacy and safety of ≥ 12-month DAPT among MMACS patients.   METHODS - In this sub-analysis of the optimal antiplatelet therapy for Chinese Patients with Coronary Artery Disease study (NCT01735305), clinical outcomes a...

Comparison of the Preventive Efficacy of Rosuvastatin Versus Atorvastatin in Post-Contrast Acute Kidney Injury in Patients With ST-segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Original Research | By YN Dai, JL Huang, DQ Yu et al.

Prognostic implications of baseline 6‐min walk test performance in intermediate risk patients undergoing transcatheter aortic valve replacement

Original Research | By J Sathananthan, P Green, M Finn et al.

BACKGROUND - While slow gait speed is known to be associated with poor outcomes in patients at high surgical risk who undergo transcatheter aortic valve replacement (TAVR), the prognostic significance of slow gait speed in intermediate risk TAVR patients is poorly understood.   OBJECTIVES - We assessed the association between baseline 6‐min walk test (6MWT) performance and both 2‐year mortality an...

Percutaneous Coronary Intervention for Chronic Total Occlusion—The Michigan Experience: Insights From the BMC2 Registry

Original Research | By H Othman, M Seth on behalf of the BMC2 Investigators.

Cardiovascular Magnetic Resonance as a complementary method to Transthoracic Echocardiography for Aortic Valve Area Estimation in patients with Aortic Stenosis: A systematic review and meta-analysis

Review Article | By TI Repanas, CA Papanastasiou, TD Karamitsos et al.

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death: A Review

Review Article | By L Muthukumar, A Jahangir, MF Jan et al.

IMPORTANCE - Malignant arrhythmic mitral valve prolapse (MVP) phenotype poses a substantial risk of sudden cardiac death (SCD), and an estimated 26 000 individuals in the United States are at risk of SCD per year. Thus, identifying risk-stratification strategies for SCD is imperative.   OBSERVATIONS - Patients with MVP have a heterogenous clinical spectrum, ranging from a benign course...

Non-obstructive High-Risk Plaques Increase the Risk of Future Culprit Lesions Comparable to Obstructive Plaques Without High-Risk Features: The ICONIC Study

Review Article | By RA Ferraro, AR van Rosendael, FY Lin et al.

AIMS - High-risk plaque (HRP) and non-obstructive coronary artery disease independently predict adverse events, but their importance to future culprit lesions has not been resolved. We sought to determine in patients prior to confirmed acute coronary syndrome (ACS) the association between lesion percent diameter stenosis (%DS), and the absolute number and prevalence of HRP. The secondary objective was to examine the relative impo...

Initial Invasive or Conservative Strategy for Stable Coronary Disease

Clinical Trial | By DJ Maron, JS Hochman and for the ISCHEMIA Research Group.

BACKGROUND - Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS- We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and m...

Infective Endocarditis After Transcatheter Aortic Valve Replacement

Original Research | By S Stortecky, D Heg, D Tueller, T Pilgrim et al.

BACKGROUND - Infective endocarditis may affect patients after transcatheter aortic valve replacement (TAVR). OBJECTIVES - The purpose of this study was to provide detailed information on incidence rates, types of microorganisms, and outcomes of infective endocarditis after TAVR. METHODS - Between February 2011 and July 2018, consecutive patients from the SwissTAV...

Optimal Stenting Technique for Complex Coronary Lesions Intracoronary Imaging-Guided Pre-Dilation, Stent Sizing, and Post-Dilation

Original Research | By H Park, J-M Ahn,S-J Park et al.

OBJECTIVES -  This study compared the 3-year outcomes of intracoronary imaging–guided pre-dilation, stent sizing, and post-dilation (iPSP) for patients with complex coronary artery lesions. BACKGROUND -  The long-term effects of the optimal drug-eluting stent implantation technique in complex coronary artery disease have not been evaluated. METHODS - From the ...

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N Engl J Med 1
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