Review Article
Volume 75, Issue 21, June 2020
JOURNAL：JACC
Article Link
Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease: JACC State-of-the-Art Review
V Narayan, EW Thompson, B Demissei et al.
KEYWORDS
biomarkers; cancer; cardio-oncology; cardiovascular disease
Cardiovascular disease (CVD) and cancer are leading causes of morbidity
and mortality worldwide. Although conventionally managed as separate
disease processes, recent research has lent insight into compelling
commonalities between CVD and cancer, including shared mechanisms for
disease development and progression. In this review, the authors discuss
several pathophysiological processes common to both CVD and cancer,
such as inflammation, resistance to cell death, cellular proliferation,
neurohormonal stress, angiogenesis, and genomic instability, in an
effort to understand common mechanisms of both disease states. In
particular, the authors highlight key circulating and genomic biomarkers
associated with each of these processes, as well as their associations
with risk and prognosis in both cancer and CVD. The purpose of this
state-of-the-art review is to further our understanding of the potential
mechanisms underlying cancer and CVD by contextualizing pathways and
biomarkers common to both diseases.
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