Clinical Trial | By A Romanov, A Cherniavskiy, N Novikova et al.
BACKGROUND - Pulmonary artery denervation (PADN) procedure has not been applied to patients with residual chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary endarterectomy (PEA). OBJECTIVES - This study sought to assess the safety and efficacy of PADN using remote magnetic navigation in patients with residual CTEPH after PEA. METHOD...
Original Research | By S Baratchi, MTK Zaldivia, M Wallert et al.
Original Research | By N Pinilla-Echeverri , SR Mehta, T Sheth et al.
BACKGROUND- Complete revascularization with routine percutaneous coronary intervention of nonculprit lesions after primary percutaneous coronary intervention improves outcomes in ST-segment–elevation myocardial infarction. Whether this benefit is associated with nonculprit lesion vulnerability is unknown. METHODS - In a prospective substudy of the COMPLETEs trial (Complete vs Culprit-Only Revasc...
Review Article | By TJ Ford, P Ong, and on behalf of the COVADIS Study Group
Considerations for Optimal Device Selection in Transcatheter Aortic Valve Replacement: A Review
Review Article | By BE Claessen, GHL Tang, AS Kini et al.
IMPORTANCE - Aortic valve stenosis (AS) is the most common manifestation of acquired valvular heart disease in developed countries. Several large-scale randomized clinical trials investigating the entire spectrum of patients with severe symptomatic AS from low to prohibitive risk have established transcatheter aortic valve replacement (TAVR) as a safe and effective alternative to surgical aortic valve replacement. ...
Timing of intervention in asymptomatic patients with valvular heart disease
Review Article | By H Baumgartner, B Iung, CM Otto.
Current management of valvular heart disease (VHD) seeks to optimize long-term outcome by timely intervention. Recommendations for treatment of patients with symptoms due to severe valvular disease are based on a foundation of solid evidence. However, when to intervene in asymptomatic patients remains controversial and decision requires careful individual weighing of the potential benefits against the risk of intervention and its long-te...
Clarification of Myocardial Infarction Types
In 1999, the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC) Committee, the forerunner of the Universal Definition of Myocardial Infarction Task Force, assembled at the European Heart House to develop a clinical set of criteria that could be used consistently to redefine the diagnosis of myocardial infarction (MI).1 Prior to that time, there had been many disparate approaches that were variations o...
Expert Opinion | By D Capodanno, MC Morice, DJ Angiolillo et al.
Investigating the balance of risk for thrombotic and bleeding events after percutaneous coronary intervention (PCI) is especially relevant for patients at high bleeding risk (HBR). The Academic Research Consortium for HBR recently proposed a consensus definition in an effort to standardize the patient population included in HBR trials. The aim of this consensus-based document, the second initiative from the Academic Research Consortium...
Leaflet immobility and thrombosis in transcatheter aortic valve replacement
Original Research | By ACT Ng, DR Holmes, MJ Mack et al.
Transcatheter aortic valve replacement (TAVR) has grown exponentially worldwide in the last decade. Due to the higher bleeding risks associated with oral anticoagulation and in patients undergoing TAVR, antiplatelet therapy is currently considered first-line antithrombotic treatment after TAVR. Recent studies suggest that some patients can develop subclinical transcatheter heart valve (THV) thrombosis after the procedure, whereby thr...
Original Research | By A Brann, S Janvanishstaporn, B Greenberg et al.
IMPORTANCE - Patients categorized as having heart failure (HF) with left ventricular ejection fraction (LVEF) in the midrange between 40% and 50% (HFmrEF) are known to be at increased risk of future events. Although patients can transition into the midrange through either improvement or deterioration in their LVEF, there is limited information available assessing the association of directional change in LVEF with future...