Clinical Trial | By P Lurz , M Unterhuber , KP Rommel et al.
Clinical Trial | By XF Gao, Z Ge, and for the ULTIMATE Investigators et al.
OBJECTIVES - This study aimed to explore the difference in target vessel failure (TVF) 3 years after intravascular ultrasound (IVUS) guidance versus angiography guidance for all-comers undergoing second-generation drug-eluting stent (DES) implantation. BACKGROUND - The multicenter randomized ULTIMATE (Intravascular Ultrasound Guided Drug Eluting Stents Implantation in “All-Comers” Coronary Lesions) tria...
Clinical Trial | By A Jeremias, JE Davies, A Maehara et al.
OBJECTIVES - This study sought to evaluate the incidence and causes of an abnormal instantaneous wave-free ratio (iFR) after angiographically successful percutaneous coronary intervention (PCI). BACKGROUND - Impaired coronary physiology as assessed by fractional flow reserve is present in some patients after PCI and is prognostically relevant. METHODS - DEFINE PCI (Physio...
Consensus | By Writing Committee, SM Lilly, AJ Deshmukh et al.
Clinical Trial | By U Baber, G Dangas, DJ Angiolillo et al.
AIMS - The aim of this study was to determine the effect of ticagrelor monotherapy on clinically relevant bleeding and major ischaemic events in relation to clinical presentation with and without non-ST elevation acute coronary syndromes (NSTE-ACS) among patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). METHODS AND RESULTS - We conducted a pre-specified...
Consensus | By F Burzotta; JF Lassen; T Lefèvre et al.
The 15th European Bifurcation Club (EBC) meeting was held in Barcelona in October 2019 and it facilitated a renewed consensus on coronary bifurcation lesions (CBL) and unprotected left main (LM) percutaneous interventions. Bifurcation stenting techniques continue to be refined, developed and tested. It remains evident that provisional approach with optional side-branch treatment utilising T, T and sma...
Clinical Trial | By RV Jeger, A Farah, BASKET-SMALL 2 Investigators et al.
BACKGROUND - In the treatment of de-novo coronary small vessel disease, drug-coated balloons (DCBs) are non-inferior to drug-eluting stents (DESs) regarding clinical outcome up to 12 months, but data beyond 1 year is sparse. We aimed to test the long-term efficacy and safety of DCBs regarding clinical endpoints in an all-comer population undergoing percutaneous coronary intervention. METHODS - In this...
Colchicine Reduces Cardiovascular Events in Chronic Coronary Disease
Clinical Trial | By SM Nidorf, ATL Fiolet, the LoDoCo2 Trial Investigators.
BACKGROUND - Evidence from a recent trial has shown that the antiinflammatory effects of colchicine reduce the risk of cardiovascular events in patients with recent myocardial infarction, but evidence of such a risk reduction in patients with chronic coronary disease is limited. METHODS - In a randomized, controlled, double-blind trial, we assigned patients with chronic coronary disease to receive 0.5 mg of colc...