Original Research | By EM DeFilippis, HGC Van Spall.
Please click on "Article Link" to get access to this article.
Original Research | By F Namazi , P van der Bijl , F Fortuni et al.
OBJECTIVES - The purpose of this study was to investigate the prognostic implications of the ratio of mitral regurgitant volume (RVol) to left ventricular (LV) end-diastolic volume (EDV) in patients with significant secondary mitral regurgitation (MR). BACKGROUND - Quantification of secondary MR remains challenging, and its severity can be over- or underestimated when using the proximal isovelocity ...
Antithrombotic Management of Elderly Patients With Coronary Artery Disease
Review Article | By P Capranzano, DJ Angiolillo.
Antithrombotic therapy represents the mainstay of treatment in patients with coronary artery disease (CAD), including elderly patients who are at increased risk for ischemic recurrences. However, the elderly population is also more vulnerable to bleeding complications. Numerous mechanisms, including abnormalities in the vasculature, thrombogenicity, comorbidities, and altered drug response, contribute to both increased thrombotic and bleed...
Clinical Trial | By J Chandrasekhar, P Anthopoulos, GD Dangas et al.
BACKGROUND - Acute kidney injury (AKI) is not uncommon in patients undergoing transcatheter aortic valve replacement (TAVR). OBJECTIVE - We examined the incidence, predictors, and outcomes of AKI from the BRAVO 3 randomized trial. METHODS - The BRAVO-3 trial included 802 patients undergoing transfemoral TAVR randomized to bivalirudin vs. unfractionated hepar...
Expert Opinion | By Nathan Bekele, MD; Molly Szerlip, MD, FACC ; Anandita Agarwala, MD
Aortic Stenosis: Aortic stenosis (AS) is one of the most prevalent forms of cardiovascular pathology in the western world, ranking only behind hypertension and coronary artery disease (CAD).1 Age is an independent risk factor for degenerative aortic valve (AV) disease, with a two-fold increased risk for each 10-year increase in age above the age of 65.1,2 According to one study, the prevalence of AS and severe AS among elderly patients ...
Long-Term Outcomes of Patients With Late Presentation of ST-Segment Elevation Myocardial Infarction
Original Research | By KH Cho , XY Han, and on behalf of the KAMIR-NIH Investigators.
BACKGROUND - Real-world data on baseline characteristics, clinical practice, and outcomes of late presentation (12 to 48 h of symptom onset) in patients with ST-segment elevation myocardial infarction (STEMI) are limited. OBJECTIVES - This study aimed to investigate real-world features of STEMI late presenters in the contemporary percutaneous coronary intervention (PCI) era. ME...
Dual antiplatelet therapy (PEGASUS) vs. dual pathway (COMPASS): a head-to-head in vitro comparison
Original Research | By CR Clifford, RG Jung, B Hibbert et al.
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is prescribed for 1-year after myocardial infarction. Two clinical strategies are considered at 1-year: continuation of DAPT or “Dual Pathway” (DP), using aspirin and rivaroxaban. No head-to-head comparative studies exist. In our in-vitro study, 24 samples of donor blood were treated with clinically proven concentrations of 5 antithrombotic regimens: aspirin, ticagr...
Consensus | By RHJA Slart, MC Williams, LE Juarez-Orozco et al.
Delirium After TAVR: Crosspassing the Limit of Resilience
Review Article | By Kvan der Wulp , MH van Wely , MJP Rooijakkers et al.
Patients who undergo transcatheter aortic valve replacement often are frail and elderly. Delirium is a frequently observed complication, associated with impaired recovery, prolonged hospital stay, and mortality. In different hospital settings, interventions that reduced the incidence of delirium resulted in improved clinical outcome and reduced costs. In that context, prevention, early recognition, and timely interventions could be the next step to...