Original Research | By S Mullane, K Michaelis, C Henrikson et al.
Original Research | By K Korsholm, JM Jensen , BL Nørgaard et al.
MITRA-FR vs. COAPT: Lessons from two trials with diametrically opposed results
Original Research | By M Brinkert, N Mangner, S Toggweiler et al.
OBJECTIVES - This study investigated whether transcatheter aortic valve replacement (TAVR) with peri-procedural continuation of oral anticoagulation is equally safe and efficacious as TAVR with peri-procedural interruption of anticoagulation. Background - A significant proportion of patients undergoing TAVR have an indication for long-term oral anticoagulation. The optimal peri-procedural management of such patients...
Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke
Clinical Trial | By RP Whitlock, EP Belley-Cote, the LAAOS III Investigators et al.
BACKGROUND - Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons. METHODS - We conducted a multicenter, randomized trial involving participants with atrial fibrillation and a CHA2DS2-VASc score of at lea...
Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest
Clinical Trial | By K Ameloot, P Jakkula, J Hästbacka et al.
BACKGROUND - In patients with shock after acute myocardial infarction (AMI), the optimal level of pharmacologic support is unknown. Whereas higher doses may increase myocardial oxygen consumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase infarct size. OBJECTIVES - This study aimed to determine the optimal mean arterial pressure (MAP) in patients with AM...
Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture
The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis
Original Research | By HI Chen , B Sharma, K Red-Horse et al.
Cellular origin and developmental program of coronary angiogenesis