Recommandation Statement | By US Preventive Services Task Force, Curry SJ, Krist AH et al.
Clinical Trial | By Smilowitz NR, Beckman JA, Sherman SE et al.
BACKGROUND - Acute myocardial infarction (AMI) is a major cardiovascular complication of noncardiac surgery. We aimed to evaluate the frequency, causes, and outcomes of 30-day hospital readmission after perioperative AMI. METHODS - Patients who were diagnosed with AMI during hospitalization for major noncardiac surgery were identified using the 2014 US Nationwide Readmission Database. Rates, causes,...
ACS Management in a Patient in Need of Noncardiac Surgery
Expert Opinion | By D Narcisse
INTRODUCTION - Patients with acute coronary syndrome (ACS) benefit from potent antithrombotic therapy and, for those with high-risk clinical features, early invasive risk stratification. This strategy reduces short- and long-term major adverse cardiac events, but it also increases the risk for bleeding. In some scenarios, the risk of bleeding may be particularly acute and predictable. For example, the care of patients who require noncardiac...
Clinical Trial | By Symons R, Pontone G, Masci PG et al.
OBJECTIVES - This study sought to investigate whether early post-infarction cardiac magnetic resonance (CMR) parameters provide additional long-term prognostic value beyond traditional outcome predictors in ST-segment elevation myocardial infarction (STEMI) patients. BACKGROUND - Long-term prognostic significance of CMR in STEMI patients has not been assessed yet. METHODS - T...
Original Research | By Patel KV, Pandey A, de Lemos JA et al.
Until recently, therapies to mitigate atherosclerotic cardiovascular disease (ASCVD) risk have been limited to lifestyle interventions, blood pressure-lowering medications, high-intensity statin therapy, antiplatelet agents, and, in select patients, coronary artery revascularization. Despite administration of these evidence-based therapies, substantial residual risk for cardiovascular events persists, particularly among individuals with known ASCVD. Mo...
Cardiac Implantable Electronic Devices in Patients With Left Ventricular Assist Systems
Expert Opinion | By Berg DD, Vaduganathan M, Stewart GC et al.
Recent progress and evolution in device engineering, surgical implantation practices, and periprocedural management have advanced the promise of durable support with left ventricular assist systems (LVAS) in patients with stage D heart failure. With greater uptake of LVAS globally, a growing population of LVAS recipients have pre-existing cardiac implantable electronic devices (CIEDs). Strategies for optimal clinical management of C...
Heart failure with preserved ejection fraction: from mechanisms to therapies
Review Article | By Lam CSP, Voors AA, de Boer RA et al.
This review aims to provide a translational perspective on recent developments in heart failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential therapies. A key concept in this review is that HFpEF is a haemodynamic condition wherein the heart fails to keep up with the circulatory demands of the body, or does so at the expense of raised left ventricular filling pressures. We, therefore, propose that the 'fi...
HFpEF: From Mechanisms to Therapies
Expert Opinion | By Ragavendra R. Baliga, M.B.B.S., FACC
The following are summary points from this article on recent developments in heart failure with preserved ejection fraction (HFpEF), which links mechanistic insights to potential therapies: 1. There is strong but indirect evidence that hypertension therapy can be beneficial in prevention of HFpEF, but less clear data on reducing morbidity or mortality in known HFpEF; aggressive blood pressure control is associat...
Clinical Trial | By Feldman T, Shah SJ, REDUCE LAP-HF I Investigators and Study Coordinators.
BACKGROUND - In nonrandomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), fewer symptoms, and greater quality of life and exercise capacity in patients with heart failure (HF) and midrange or preserved ejection fraction (EF ≥40%). We conducted the first randomized sham-controlled trial to evaluate the IASD in...
Clinical Trial | By Adamson PB, Abraham WT, Bourge RC et al.
BACKGROUND - In nonrandomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), fewer symptoms, and greater quality of life and exercise capacity in patients with heart failure (HF) and midrange or preserved ejection fraction (EF ≥40%). We conducted the first randomized sham-controlled trial to evaluate the IASD in HF ...