Clinical Trial | By Bilchick KC, Wang Y, Cheng A et al.
BACKGROUND - Recent clinical trials highlight the need for better models to identify patients at higher risk of sudden death. OBJECTIVES - The authors hypothesized that the Seattle Heart Failure Model (SHFM) for overall survival and the Seattle Proportional Risk Model (SPRM) for proportional risk of sudden death, including death from ventricular arrhythmias, would predict the survival benefit wit...
Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction
Clinical Trial | By B Levy, R Clere-Jehl, A Legras et al.
BACKGROUND - Vasopressor agents could have certain specific effects in patients with cardiogenic shock (CS) after myocardial infarction, which may influence outcome. Although norepinephrine and epinephrine are currently the most commonly used agents, no randomized trial has compared their effects, and intervention data are lacking. OBJECTIVES - The goal of this paper was to compare in a prospective, double-blind, ...
Clinical Trial | By Saito S, Krucoff MW, Nakamura S et al.
AIMS - Harmonized Assessment by Randomized Multicentre Study of OrbusNEich's Combo StEnt (HARMONEE) (NCT02073565) was a randomized pivotal registration trial of the Combo stent, which combined sirolimus and an abluminal bioabsorbable polymer with a novel endoluminal anti-CD34+ antibody coating designed to capture endothelial progenitor cells (EPC) and promote percutaneous coronary intervention (PCI) site healin...
Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions
Expert Opinion | By Carlyn Tan, MD; Crystal Denlinger, MD
Introduction - An individual is defined by the National Cancer Institute as a survivor "from the time of diagnosis through the balance of his or her life."1 Due to improved diagnosis and treatment, the number of cancer survivors in the United States reached nearly 15.5 million currently.2,3 More than 60% and 40% of cancer survivors are alive 5 and ≥10 years after diagnosis, respectively, contributing to a growing population of aging survivors at risk for l...
Clinical Trial | By AH Gershlick, DE Kandzari, GW Stone et al.
OBJECTIVES - The authors sought to determine the extent to which the site of the left main coronary artery (LM) lesion (distal bifurcation versus ostial/shaft) influences the outcomes of revascularization with percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG). BACKGOURND - Among 1,905 patients with LM disease and site-assessed SYNTAX scores of <32 randomized in ...
Clinical Trial | By PW Serruys, R Cavalcante, GW Stone et al.
OBJECTIVES - The aim of the present study was to assess outcomes after coronary artery bypass grafting surgery (CABG) and percutaneous coronary intervention (PCI) according to sex in a large randomized trial of patients with unprotected left main disease. BACKGOURND - In the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial, sex had a significant interac...
Long-Term Clinical Outcomes and Optimal Stent Strategy in Left Main Coronary Bifurcation Stenting
Clinical Trial | By S Cho, TS Kang, J-S Kim et al.
OBJECTIVES - This study sought to investigate the long-term clinical effects of stent generation and stent strategy for left main coronary artery (LMCA) bifurcation lesion treatment. BACKGROUD - Limited data are available to assess long-term clinical outcomes after stenting, including use of current-generation drug-eluting stent (C-DES) for treatment of LMCA bifurcation lesions. METHODS ...
Complex PCI procedures: challenges for the interventional cardiologist
Review Article | By Werner N, Nickenig G, Sinning JM.
In recent years, the percentage of patients with multivessel disease and multiple complex stenoses have significantly increased. One factor contributing to this increase is the proportion of elderly and very elderly patients who have been turned down by the Heart Team for surgical revascularization (Landes et al. in Catheter Cardiovasc Interv, https://doi.org/10.1002/ccd.27375 , 2017; Waldo et al. in Circulation 130:2295-2301, https://doi.org/10.116...
Original Research | By Waldo SW, Secemsky EA, Yeh RW et al.
BACKGROUND - Decisions to proceed with surgical versus percutaneous revascularization for multivessel coronary artery disease are often based on subtle clinical information that may not be captured in contemporary registries. The present study sought to evaluate the association between surgical ineligibility documented in the medical record and long-term mortality among patients with unprotected left main or multivessel corona...
Original Research | By Landes U, Bental T, Levi A et al.
BACKGROUND - The last decade, regarded as the DES era in PCI, has witnessed significant advances in the management of coronary disease. We aimed to assess temporal trends in the practice and outcome of percutaneous coronary intervention (PCI) during the drug eluting stent (DES) era. METHODS - We analyzed 18,641 consecutive PCI's performed between January 2004 and December 2016, distinguished by procedural d...