Original Research | By Prati F, Romagnoli E, Mintz GS et al.
High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction
Original Research | By AKumar, EW Thompson, A Lefieux et al.
BACKGROUND - Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability. OBJECTIVES - This study investigated the prognostic value of WSS measured in the proximal segments of lesions (WSSprox) to predict myocardial infarction (M...
Review Article | By Zhang JY, Farooq V, Chen SL et al.
AIMS - The impact of intravascular ultrasound (IVUS) guided coronary drug-eluting stent(DES) implantation on clinical outcomes remains controversial. A meta-analysis of the currently available clinical trials investigating IVUS-guided DES implantation was undertaken. METHODS AND RESULTS - We searched Medline, the Cochrane Library and other internet sources, without language or date restrictions, for publ...
Review Article | By Klersy C, Ferlini M, Raisaro A et al.
BACKGROUND/OBJECTIVES - Long term safety of DES, particularly regarding thrombosis is of concern. The hypothesized underlying mechanisms (stent under expansion, malapposition) could be prevented by IVUS guidance. Aim of this meta-analysis of randomized controlled clinical trials (RCT) and high quality observational cohort studies (HQ-OBS) is to quantify the potential clinical benefit of intravascular ultrasou...
Review Article | By Ahn JM, Kang SJ, Park SJ et al.
There are conflicting data regarding the benefit of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) over angiography-guided PCI. Since the last meta-analysis was published, several new studies have been reported. We performed a comprehensive meta-analysis to evaluate the clinical impact of IVUS-guided PCI with drug-elutingstent compared with conventional angiography-guided PCI. This meta-analysis ...
Pulmonary Arterial Hypertension With Abnormal V/Q Single-Photon Emission Computed Tomography
Original Research | By K Chan, S Ioannidis, JG Coghlan et al.
OBJECTIVES - This study aimed to evaluate the incidence and clinical outcomes of abnormal ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT) without thromboembolism, especially in patients with group I pulmonary arterial hypertension (PAH). BACKGROUND - American Heart Association/American College of Cardiology and European Society of Cardiol...
Original Research | By Andell P, Karlsson S, Mohammad MA et al.
Original Research | By AS Bhatt, L Liang, AD DeVore et al.
OBJECTIVES - This study sought to evaluate and contribute to the limited data on U.S. hospital practice patterns with respect to respiratory vaccination in patients hospitalized with heart failure (HF). BACKGROUND - Respiratory infection is a major driver of morbidity in patients with HF, and many influenza and pneumococcal infections may be prevented by vaccination. ...
Clinical Trial | By K Sharma, Stuart D. Russell and on behalf of the Osler Medical Housestaff.
OBJECTIVES - This study sought to compare a continuous infusion diuretic strategy versus an intermittent bolus diuretic strategy, with the addition of low-dose dopamine (3 μg/kg/min) in the treatment of hospitalized patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND - HFpEF patients are susceptible to development of worsening renal function (WRF) when ...