Clinical Trial | By AH Larsen, H Wiggers, Niels Jessen et al.
PURPOSE - The glucose-lowering drug metformin has recently been shown to reduce myocardial oxygen consumption and increase myocardial efficiency in chronic heart failure (HF) patients without diabetes. However, it remains to be established whether these beneficial myocardial effects are associated with metformin-induced alterations in whole-body insulin sensitivity and substrate metabolism. METHODS - Eighteen H...
Original Research | By MB Tsang, JD Schwalm, S Gandhi et al.
Original Research | By L Asmarats, G O'Hara, J Champagne et al.
BACKGROUND - The impact of antithrombotic therapy on coagulation system activation after left atrial appendage closure (LAAC) remains unknown. This study sought to compare changes in coagulation markers associated with short-term oral anticoagulation (OAC) versus antiplatelet therapy (APT) following LAAC. METHODS - Prospective study including 78 atrial fibrillation patients undergoing LAAC...
Original Research | By S He, J Wu, RK Li et al.
Myocardial fibrosis, resulting from ischemic injury, increases tissue resistivity in the infarct area, which impedes heart synchronous electrical propagation. The uneven conduction between myocardium and fibrotic tissue leads to dys-synchronous contraction, which progresses towards ventricular dysfunction. We synthesized a conductive poly-pyrrole-chitosan hydrogel (PPY-CHI), and investigated its capabilities in improving electrical propagation...
Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review
Review Article | By SN Hayes, MS Tweet, D Adlam et al.
Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an important cause of myocardial infarction, particularly among younger women. The pace of knowledge acquisition has been rapid, but ongoing challenges include accurately diagnosing SCAD and improving outcomes. Many SCAD patients experience substantial post-SCAD symptoms, recurrent SCAD, and psychosocial distress. Considerable uncertainty remai...
Raising the Evidentiary Bar for Guideline Recommendations for TAVR: JACC Review Topic of the Week
On August 16, 2019, the U.S. Food and Drug Administration approved expanding the indication for transcatheter aortic valve replacement (TAVR) to low-risk patients with symptomatic severe aortic stenosis. The decision was based on the results of 2 pivotal trials that confirmed superiority (PARTNER [Placement of Aortic Transcatheter Valves] 3) or noninferiority (Evolut Low Risk [LR]) of TAVR as compared with SAVR at ...
Clinical Trial | By K Ejiri, T Miyoshi, MUSCAT‐HF Study Investigators.
Clinical Trial | By A Romanov, A Cherniavskiy, N Novikova et al.
BACKGROUND - Pulmonary artery denervation (PADN) procedure has not been applied to patients with residual chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary endarterectomy (PEA). OBJECTIVES - This study sought to assess the safety and efficacy of PADN using remote magnetic navigation in patients with residual CTEPH after PEA. METHODS ...
Original Research | By S Baratchi, MTK Zaldivia, M Wallert et al.