Original Research | By J Hyun, J H Kim, MAIN-COMPARE Registry.
Review Article | By D Cao, R Chandiramani, M Chiarito et al.
Since its introduction in 1977, percutaneous coronary intervention has become one of the most commonly performed therapeutic procedures worldwide. Such widespread diffusion, however, would have not been possible without a concomitant evolution of the pharmacotherapies associated with this intervention. Antithrombotic agents are fundamental throughout the management of patients undergoing coronary stent implantation, starting from the proc...
Is Acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF
Review Article | By BA Davison, S Senger, IE Sama et al.
AIMS -This retrospective analysis sought to identify markers that might distinguish between acute heart failure (HF) and worsening HF in chronic outpatients. METHODS AND RESULTS -The BIOSTAT‐CHF index cohort included 2516 patients with new or worsening HF symptoms: 1694 enrolled as inpatients (acute HF) and 822 as outpatients (worsening HF in chronic outpatients). A validati...
Original Research | By AA Matthews, SP Hinton, S Stanway et al.
Original Research | By G Bugani, M Pagnesi, D Tchetchè et al.
OBJECTIVES - To define the incidence of high residual gradient (HRG) after transcatheter aortic valve replacement (TAVR) in BAVs and their impact on short term outcome and 1-year mortality. BACKGROUND - Transcatheter heart valves (THVs) offer good performance in tricuspid aortic valves with low rate of HRG. However, data regarding their performance in bicuspid aortic valves (BAV) are still lacking. ...
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
Original Research | By AA Cluntun, R Badolia, SG Drakos et al.
The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF). These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an increased export of lactate. We identify the mitochondrial pyruvate carrier (MPC) and the cellular lactate exporter monocarboxylate transporter 4 (MCT4) as pivotal nodes in this metabolic axis. We observed that cardiac assist device-induced myocardial recovery i...
Original Research | By CJ Kobylecki, BG Nordestgaard, S Afzal et al.
BACKGROUND - Circulating total calcium or albumin-adjusted calcium is a risk factor for cardiovascular disease. As the biologically active ionized calcium is a physiologically more relevant measure and its association with cardiovascular disease is poorly understood, we tested the hypothesis that high plasma ionized calcium is associated with higher risk of myocardial infarction and ischemic stroke in individuals in the g...
Original Research | By SAJ Damen, GE Cramer, H-J Dieker et al.
Unexpectedly Low Natriuretic Peptide Levels in Patients With Heart Failure