Original Research | By R von Känel, J-P Schmid, RE Meister-Langraf et al.
Original Research | By GG Schwartz, PG Steg, ODYSSEY OUTCOMES Committees and Investigators et al.
Cardiac Resynchronization Therapy and Ventricular Tachyarrhythmia Burden
Original Research | By S Tankut, I Goldenberg, V Kutyifa et al.
BACKGROUND - Cardiac resynchronization therapy-defibrillator (CRT-D) may reduce the incidence of first ventricular tachyarrhythmia (VTA) in patients with heart failure (HF) and left bundle-branch-block (LBBB). OBJECTIVE - To assess the effect of CRT-D on VTA burden in LBBB patients. METHODS - We included 1281 patients with LBBB from MADIT-CR...
When and how to use SGLT2 inhibitors in patients with HFrEF or chronic kidney disease
Original Research | By RD Kurmann, EA El-Am, YA Radwan et al.
Clinical Trial | By Z Ge, JJ Zhang, SL Chen et al.
BACKGROUND - Double kissing (DK) crush approach for patients with coronary bifurcation lesions, particularly localized at distal left main or lesions with increased complexity, is associated with significant reduction in clinical events when compared with provisional stenting (PS). Recently, randomized clinical trial has demonstrated the net clinical benefits by intravascular ultrasound (IVUS)-guided implantation of drug-eluting stent (D...
Circulating MicroRNAs and Monocyte-Platelet Aggregate Formation in Acute Coronary Syndrome
Original Research | By S Stojkovic, PP Wadowski, P Haider et al.
BACKGROUND - Monocyte-platelet aggregates (MPAs) are a sensitive marker of in vivo platelet activation in acute coronary syndrome (ACS) and associated with clinical outcomes. MicroRNAs (miRs) play an important role in the regulation of platelet activation, and may influence MPA formation. Both, miRs and MPA, could be influenced by the type of P2Y12 inhibitor. AIM - To study the a...
Late kidney injury after transcatheter aortic valve replacement
Original Research | By Y Adachi, M Yamamoto, OCEAN-TAVI investigators et al.
BACKGROUND - Information on early to late-phase kidney damage in patients who underwent transcatheter aortic valve replacement (TAVR) is scarce. We aimed to identify the predictive factors for late kidney injury (LKI) at 1-year and patient prognosis beyond 1-year after TAVR. METHODS - We retrospectively reviewed 1705 patients’ data from the Japanese TAVR multicenter registry. Acute kidney in...
Microthrombi As A Major Cause of Cardiac Injury in COVID-19: A Pathologic Study
Original Research | By D Pellegrini, R Kawakami, G Guagliumi et al.