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Validation of bifurcation DEFINITION criteria and comparison of stenting strategies in true left main bifurcation lesions

Original Research | By J Wang, SB Qiao, B Xu et al.

Impact of Lesion Preparation Strategies on Outcomes of Left Main PCI: The EXCEL Trial

Clinical Trial | By N Beohar, S Chen, GW Stone et al.

OBJECTIVES - We examined outcomes according to lesion preparation strategy (LPS) in patients with left main coronary artery (LMCA) percutaneous coronary intervention (PCI) in the EXCEL trial.   BACKGROUND - The optimal LPS for LMCA PCI is unclear.   METHODS - We categorized LPS hierarchically (high to low) as: (a) rotational atherectomy (RA); (b) cut...

Inflammatory Bowel Disease and Acute Coronary Syndromes: From Pathogenesis to the Fine Line Between Bleeding and Ischemic Risk

Review Article | By M Pepe, E Carulli, Cinzia Forleo et al.

Inflammatory bowel disease (IBD) is a pathological condition that first involves the gastrointestinal wall but can also trigger a systemic inflammatory state and thus extraintestinal manifestations. Systemic inflammation is probably secondary to the passage of bacterial products into the bloodstream because of altered intestinal permeability and the consequent release of proinflammatory mediators. Inflammation, through several dive...

Identifying coronary artery disease patients at risk for sudden and/or arrhythmic death: remaining limitations of the electrocardiogram

Editorial | By B Asatryan, L Roten, T Reichlin et al.

The important study concerning the easy-to-use electrocardiogram (ECG) markers of sudden and/or arrhythmic death (SAD) in coronary artery disease (CAD) patients as presented by Chatterjee et al.1 is a weighty contribution to an intricate and still rather puzzling topic. They implicate that in CAD patients, contiguous Q waves, left ventricular hypertrophy (LVH), QRS duration, and JTc prolongation provide incremental predictive value...

Simple Electrocardiographic Measures Improve Sudden Arrhythmic Death Prediction in Coronary Disease

Original Research | By NA Chatterjee, JT Tikkanen, PREDETERMINE Investigators et al.

AIMS -  To determine whether the combination of standard electrocardiographic (ECG) markers reflecting domains of arrhythmic risk improves sudden and/or arrhythmic death (SAD) risk stratification in patients with coronary heart disease (CHD).   METHODS AND RESULTS -  The association between ECG markers and SAD was examined in a derivation cohort (PREDETERMINE; N = 5462) ...

Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome

Review Article | By W Bor, DA Gorog.

Determinants and Impact of Heart Failure Readmission Following Transcatheter Aortic Valve Replacement

Original Research | By V Auffret, A Bakhti, G Leurent et al.

BACKGROUND - Heart failure (HF) readmission is common post-transcatheter aortic valve replacement (TAVR). Nonetheless, limited data are available regarding its predictors and clinical impact. This study evaluated the incidence, predictors, and impact of HF readmission within 1-year post-TAVR, and assessed the effects of the prescription of HF therapies at discharge on the risk of HF readmission and death. ...

Comparison of 1-Year Pre- And Post-Transcatheter Aortic Valve Replacement Hospitalization Rates: A Population-Based Cohort Study

Original Research | By A Czarnecki, F Qiu, KA Henning et al.

BACKGROUND - Rehospitalization rates post-transcatheter aortic valve replacement (TAVR) are high; however, it is not known how these compare with pre-TAVR hospitalization rates. Our objective was to determine the association between the index TAVR and hospitalization rates pre- and postprocedure. METHODS - A retrospective observational study was performed including all TAVR procedures perform...

Discrepancies in Measurement of the Thoracic Aorta: JACC Review Topic of the Week

Review Article | By JA Elefteriades, SK Mukherjee, H Mojibian et al.

Clinicians often encounter discrepant measurements of the ascending aorta that impede, complicate, and impair appropriate clinical assessment—including key issues of presence or absence of aortic growth, rate of growth, and need for surgical intervention. These discrepancies may arise within a single modality (computed tomography scan, magnetic resonance imaging, or echocardiography) or between modalities. The authors explore the origins an...

Precision Medicine in TAVR: How to Select the Right Device for the Right Patient

Editorial | By G Marquis-Gravel, S Vemulapalli, AW Asgar et al.

Transcatheter aortic valve replacement (TAVR) represents a first-line option for the treatment of patients with severe symptomatic aortic stenosis across the entire spectrum of surgical risks. Given the expected growth of TAVR procedures in low-risk patients, many factors other than the primary endpoints of pivotal TAVR trials (either death, or the composite of death or stroke) need to be considered during the selection ...

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左主干暨冠状动脉分叉病变峰会

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