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Impact of Incomplete Coronary Revascularization on Late Ischemic and Bleeding Events after Transcatheter Aortic Valve Replacement

Original Research | By A Carmona, B Marchandot, F Severac et al.

The Impact of Coronary Physiology on Contemporary Clinical Decision Making

Review Article | By N Kogame, M Ono, PW Serruys et al.

Physiological assessment of coronary artery disease (CAD) has become one of the cornerstones of decision making for myocardial revascularization, with a large body of evidence supporting the benefits of using fractional flow reserve and other pressure-based indexes for functional assessment of coronary stenoses. Furthermore, physiology allows the identification of specific vascular dysfunction mechanisms in patients without obstructive CAD. ...

A Prospective, Multicenter, Randomized, Open-label Trial to Compare Efficacy and Safety of Clopidogrel vs. Ticagrelor in Stabilized Patients with Acute Myocardial Infarction after Percutan eous Coronary Intervention: rationale and design of the TALOS-AMI trial

Clinical Trial | By M-W Park, CJ Kim, K Chang et al.

AIMS - In patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI), the risk of ischemic complications is highest in early phase (during the first 30days), while most bleeding events predominantly occur during maintenance phase of treatment (after the first 30days). Data on the de-escalating dual antiplatelet therapy of switching from ticagrelor to clopidogrel in stabilized AMI patients are limi...

Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel

Review Article | By JE Wilcox, JC Fang, KB Margulies et al.

Reverse left ventricular (LV) remodeling and recovery of LV function are associated with improved clinical outcomes in patients with heart failure with reduced ejection fraction. A growing body of evidence suggests that even among patients who experience a complete normalization of LV ejection fraction, a significant proportion will develop recurrent LV dysfunction accompanied by recurrent heart failure events. This has led to intense in...

Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress

Review Article | By LJ He, NB Nguyen, R Ardehali et al.

New technologies for intensive prevention programs after myocardial infarction: rationale and design of the NET-IPP trial

Clinical Trial | By H Wienbergen, A Fach, J Erdmann et al.

INTRODUCTION - Current health care data reveal suboptimal prevention in patients with coronary artery disease and an unmet need to develop effective preventive strategies. The New Technologies for Intensive Prevention Programs (NET-IPP) Trial will investigate if a long-term web-based prevention program after myocardial infarction (MI) will reduce clinical events and risk factors. In a genetic sub study the impact of ...

Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for acute coronary syndrome patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double-blinded, placebo-controlled randomized trial

Clinical Trial | By Yi Li, QM Jing, YL Han et al.

BACKGROUND - Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor is the cornerstone for prevention ischemic events in patients with acute coronary syndromes (ACS) and undergoing percutaneous coronary intervention. However, the optimal antiplatelet strategy for ACS patients with both high bleeding and high ischemic risks is unclear. STUDY DESIGN - The OPT-BIRISK trial is a multicenter, ...

Impaired Retinal Microvascular Function Predicts Long-Term Adverse Events in Patients with Cardiovascular Disease

Original Research | By JD Theuerle, AH Al-Fiadh, FMA Islam et al.

AIMS - Endothelial dysfunction is a precursor to the development of symptomatic atherosclerosis. Retinal microvascular reactivity to flicker light stimulation is a marker of endothelial function and can be quantified in vivo. We sought to determine whether retinal microvascular endothelial dysfunction predicts long-term major adverse cardiovascular events (MACE). METHODS AND RESULTS - In a single cent...

Non-cardiac surgery in patients with coronary artery disease: risk evaluation and periprocedural management

Review Article | By D Cao, R Chandiramani, R Mehran et al.

Perioperative cardiovascular complications are important causes of morbidity and mortality associated with non-cardiac surgery, particularly in patients with coronary artery disease (CAD). Although preoperative cardiac risk assessment can facilitate the identification of vulnerable patients and implementation of adequate preventive measures, excessive evaluation might lead to undue resource utilization and surgical delay. Owing to conflicting ...

Third-Generation Balloon and Self-Expandable Valves for Aortic Stenosis in Large and Extra-Large Aortic Annuli From the TAVR-LARGE Registry

Original Research | By G Armijo, GHL Tang, N Kooistra et al.

BACKGROUND - Currently, 2 third-generation transcatheter valves, 29-mm Sapien-3 and 34-mm Evolut-R (ER), are indicated for large sized aortic annuli. We analyzed short and 1-year performance of these valves in patients with large (area ≥575 mm2or perimeter ≥85 mm) and extra-large (≥683 mm2or ≥94.2 mm) aortic annuli undergoing transcatheter aortic valve replacement.   METHODS - A total of 8...

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Original Research 785
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Clinical Case Study 28
Clinical Trial 415
Perspective 9
Guideline 50

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2020 10

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Nat Rev Cardiol. 1
JACC: Cardiovascular Interventions 1
J Clin Med. 1
J Am Coll Cardiol. 1
Eurointervention. 1
Clin Res Cardiol. 1
Circulation. 1
Circ Cardiovasc Interv . 1
Cardiovasc Res . 1
Am Heart J. 1

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