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Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI

Original Research | By G Marquis-Gravel, F Dalgaard, AD Jones et al.

BACKGROUND - The long-term prognostic impact of post-discharge bleeding in the unique population of patients with acute coronary syndrome (ACS) treated without percutaneous coronary intervention (PCI) remains unexplored.   OBJECTIVES - The aim of this study was to assess the association between post-discharge bleeding and subsequent mortality after ACS according to index strategy (PCI or no PCI) and t...

Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

Original Research | By AR Orkaby, JA Driver, Y-L Ho et al.

IMPORTANCE - Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults 75 years and older. OBJECTIVE - To evaluate the role of statin use for mortality and primary prevention of ASCVD in veterans 75 years and older. DESIGN, SETTING, AND PARTICIPANTS - Retrospective cohort study that used Veterans Heal...

The Prognostic Significance of Periprocedural Infarction in the Era of Potent Antithrombotic Therapy: The PRAGUE-18 Substudy

Original Research | By J Dusek, Z Motovska, Prague-18 Study Group et al.

BACKGROUND - The prognostic significance of periprocedural myocardial infarction (MI) remains controversial. METHODS AND RESULTS - The study aims to investigate the incidence of periprocedural MI in the era of high sensitivity diagnostic markers and intense antithrombotics, and its impact on early outcomes of patients with acute MI treated with primary angioplasty (pPCI). Data from the PRA...

Acute Coronary Syndrome, Antiplatelet Therapy, and Bleeding: A Clinical Perspective

Review Article | By G Tersalvi, L Biasco, GM Cioffi et al.

Transcatheter Aortic Valve Replacement in Patients With Multivalvular Heart Disease

Review Article | By F Khan, T Okuno, D Malebranche et al.

As transcatheter aortic valve replacement becomes a more dominant treatment option across all risk profiles, the frequency of encountering patients with multivalvular disease will increase. Furthermore, percutaneous interventions to treat other valvular lesions are also evolving. Understanding the clinical implications and treatment options for a second valvular lesion is becoming increasingly important to guide heart team decisions, and this p...

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling

Original Research | By BAT Rodriguez, A Bhan, A Beswick et al.

Dual antiplatelet therapy reduces ischemic events in cardiovascular disease, but it increases bleeding risk. Thrombin receptors PAR1 and PAR4 are drug targets, but the role of thrombin in platelet aggregation remains largely unexplored in large populations. We performed a genome-wide association study (GWAS) of platelet aggregation in response to full-length thrombin, followed by clinical association analyses, Mendelian ra...

Valve‐in‐Valve for Degenerated Transcatheter Aortic Valve Replacement Versus Valve‐in‐Valve for Degenerated Surgical Aortic Bioprostheses: A 3‐Center Comparison of Hemodynamic and 1‐Year Outcome

Original Research | By MC Raschpichler, F Woitek, T Chakravarty et al.

Bioprosthetic valve oversizing is associated with increased risk of valve thrombosis following TAVR

Original Research | By TF Simpson, CV Tuohy, K Rajotte et al.

BACKGROUND - Hypoattenuating leaflet thickening (HALT), the radiographic manifestation of transcatheter heart valve thrombosis, is commonly identified following transcatheter aortic valve replacement (TAVR) and associated with increased risk of stroke and structural valve deterioration. While anticoagulation effectively resolves HALT, routine use remains controversial. We aimed to identify hemodynamic, anatomic, and co...

Long-term outcome of prosthesis-patient mismatch after transcatheter aortic valve replacement

Original Research | By M Compagnone, G Marchetti, F Saia et al.

BACKGROUND - Incidence and long-term clinical consequences of prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) are still unclear. METHODS - We enrolled 710 consecutive patients who underwent TAVR. PPM was defined as absent if the index orifice area (iEOA) was >0.85 cm2/m2, moderate if the iEOA was betw...

Feasibility and efficacy of the ultrashort side branch dedicated balloon in coronary bifurcation stenting

Original Research | By Y Murasato, M Nishihara, T Mori et al.

AIMS - We sought to investigate the feasibility and efficacy of the Glider balloon (GB), a side branch (SB) dedicated balloon 4-mm in length, in coronary bifurcation stenting. METHODS AND RESULTS - In bifurcation bench models, stent configuration was examined with micro-focus computed tomography after crossover stenting followed by GB dilation or kissing balloon inflation (KBI). GB dilation maintaine...

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Original Research 785
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Int J Cardiol . 1
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Eurointervention. 1
Catheter Cardiovasc Interv . 1
Am J Hum Genet. 1

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