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Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes A Combination of Allogeneic Stem Cells Promotes Cardiac Regeneration Long-Term Outcomes in Women and Men Following Percutaneous Coronary Intervention Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity Association Between Living in Food Deserts and Cardiovascular Risk
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Review Article2017 Jul 11;70(2):230-251.

JOURNAL：J Am Coll Cardiol. Article Link

Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series

Niemann B, Newby DE, Kovacic JC et al. Keywords: air pollution; atherosclerosis; diabetes; exhaust; inflammation; metabolic stress; obesity; particulate matter; tobacco

ABSTRACT

Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting. Here, we explore the role of different ROS sources arising in obesity and diabetes, and the effect of excessive ROS production on the development of cardiac lipotoxicity. In parallel, contaminants in the air that we breathe pose a significant threat to human health. This paper provides an overview of cigarette smoke and urban air pollution, considering how their composition and biological effects have detrimental effects on cardiovascular health.



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