Outcome of Applying the ESC 0/1-hour Algorithm in Patients With Suspected Myocardial Infarction
Original Research | By R Twerenbold, JP Costabel, T Nestelberger et al.
BACKGROUND - The European Society of Cardiology (ESC) recommends the 0/1-h algorithm for rapid triage of patients with suspected non–ST-segment elevation myocardial infarction (MI). However, its impact on patient management and safety when routinely applied is unknown. OBJECTIVES - This study sought to determine these important real-world outcome data. METHODS - ...
Application of High-Sensitivity Troponin in Suspected Myocardial Infarction
Original Research | By JT Neumann, R Twerenbold, F Ojeda et al.
BACKGROUND - Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful in determining the probability of myocardial infarction and subsequent 30-day outcomes. METHODS - In 15 international cohorts of patients presenting to the emergency department with symptoms suggestive of myocardial in...
Original Research | By Basir MB, Kapur NK, National Cardiogenic Shock Initiative Investigators.
BACKGROUND - The National Cardiogenic Shock Initiative is a single-arm, prospective, multicenter study to assess outcomes associated with early mechanical circulatory support (MCS) in patients presenting with acute myocardial infarction and cardiogenic shock (AMICS) treated with percutaneous coronary intervention (PCI). METHODS - Between July 2016 and February 2019, 35 sites participated and enrolled into ...
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
Clinical Trial | By Wallentin L, PLATO Investigators, Thorsén M.
BACKGROUND - Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel. METHODS - In this multicenter, double-blind, randomized trial, we compared ticagrelor (180-mg loading dose, 90 mg twice daily thereafter) and clopidogrel (300-to-600-mg loading dose, 75 mg daily thereafter) for the pr...
Prasugrel versus clopidogrel in patients with acute coronary syndromes
Clinical Trial | By Wiviott SD, Braunwald E, TRITON-TIMI 38 Investigators.
BACKGROUND - Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention. METHODS - To compare prasugrel, a new thienopyridine, with clopidogrel, we randomly assigned 13,608 patients with moderate-to-high-risk acute coronary syndromes with scheduled percutaneous coronary intervention to receive...
Original Research | By Sahlén A, Varenhorst C, Lagerqvist B et al.
The right ventricle in pulmonary hypertension
Review Article | By Chin KM, Kim NH, Rubin LJ.
Pulmonary arterial hypertension (PAH) is a term used to classify a variety of conditions that share in common an injury to the pulmonary vasculature that produces elevations in pulmonary arterial pressure. However, it is the integrity of right ventricular function, rather than the degree of vascular injury, that is the major determinant of symptoms and survival in PAH. The article will review the normal structure and function of the right...
Mechanical circulatory support devices for acute right ventricular failure
Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults
Original Research | By Miedema MD, Dardari ZA, Nasir K et al.
Original Research | By Motreff P, Rioufol G, Gilard M et al.
AIMS - Angiographic analysis of left main coronary artery (LMCA) stenosis can be hindered by the lack of any reference segment when the LMCA is short or there is diffuse atheroma. Fractal geometric law (FGL) enables the theoretic diameter of one bifurcation vessel to be calculated from those of the other two (Dmother=0.678*(Ddaughter1+Ddaughter2). Applied to the LMCA, the FGL can help the quantification of stenoses. MET...