Review Article | By Ando T, Ashraf S, Villablanca P et al.
Transcatheter aortic valve implantation (TAVI) has been used to treat high surgical risk cohorts but has been expanded to treat low-to-intermediate risk cohort as well. We performed a systematic review and meta-analysis to compare the outcomes between TAVI and surgical aortic valve replacement (SAVR) in low-to-intermediate risk cohort. We queried PUBMED, EMBASE, and ClinicalTrial.gov for relevant articles. Randomized con...
Original Research | By Thourani VH, Suri RM, Gunter RL et al.
Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients
Clinical Trial | By Popma JJ, Deeb GM, Evolut Low Risk Trial Investigators.
BACKGROUND - Transcatheter aortic-valve replacement (TAVR) is an alternative to surgery in patients with severe aortic stenosis who are at increased risk for death from surgery; less is known about TAVR in low-risk patients. METHODS - We performed a randomized noninferiority trial in which TAVR with a self-expanding supraannular bioprosthesis was compared with surgical aortic-valve replace...
Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients
Clinical Trial | By Mack MJ, Leon MB, PARTNER 3 Investigators.
BACKGROUND - Among patients with aortic stenosis who are at intermediate or high risk for death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. There is insufficient evidence regarding the comparison of the two procedures in patients who are at low risk. METHODS - We randomly assigned patients with severe aorti...
Clinical Trial | By Nielsen HH1, Klaaborg KE, Nissen H et al.
AIMS - In a prospective randomised trial we aimed to compare transapical transcatheter aortic valve implantation (a-TAVI) with surgical aortic valve replacement (SAVR) in operable elderly patients. METHODS AND RESULTS - The study was designed as a randomised controlled trial of a-TAVI (Edwards SAPIEN heart valve system; Edwards Lifesciences, Irvine, CA, USA) vs. SAVR....
Transcatheter aortic-valve replacement with a self-expanding prosthesis
Clinical Trial | By Adams DH, Popma JJ, U.S. CoreValve Clinical Investigators.
BACKGROUND - We compared transcatheter aortic-valve replacement (TAVR), using a self-expanding transcatheter aortic-valve bioprosthesis, with surgical aortic-valve replacement in patients with severe aortic stenosis and an increased risk of death during surgery. METHODS - We recruited patients with severe aortic stenosis who were at increased surgical risk as determined by the heart team at each stud...
Clinical Trial | By Thyregod HG, Steinbrüchel DA, Ihlemann N et al.
Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients
Clinical Trial | By Leon MB, Smith CR, PARTNER 2 Investigators.
BACKGROUND - Previous trials have shown that among high-risk patients with aortic stenosis, survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. We evaluated the two procedures in a randomized trial involving intermediate-risk patients. METHODS - We randomly assigned 2032 intermediate-risk patients with severe aortic stenosis, at 57 centers, to und...
Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients
Original Research | By Reardon MJ, Van Mieghem NM, SURTAVI Investigators.
BACKGROUND - Although transcatheter aortic-valve replacement (TAVR) is an accepted alternative to surgery in patients with severe aortic stenosis who are at high surgical risk, less is known about comparative outcomes among patients with aortic stenosis who are at intermediate surgical risk. METHODS - We evaluated the clinical outcomes in intermediate-risk patients with severe, symptomatic aortic ste...