Consensus | By Lassen JF, Burzotta F, Banning AP et al.
The European Bifurcation Club (EBC) was initiated in 2004 to support a continuous overview of the field of coronary artery bifurcation interventions and aims to facilitate a scientific discussion and an exchange of ideas on the management of bifurcation disease. The EBC hosts an annual, two-day compact meeting, dedicated to bifurcations, which brings together physicians, pathologists, engineers, biologists, physicists, mathematicia...
Original Research | By Wehner GJ, Jing L, Haggerty CM et al.
AIMS - We investigated the relationship between clinically assessed left ventricular ejection fraction (LVEF) and survival in a large, heterogeneous clinical cohort. METHODS AND RESULTS - Physician-reported LVEF on 403 977 echocardiograms from 203 135 patients were linked to all-cause mortality using electronic health records (1998-2018) from US regional healthcare system. Cox proportional hazards ...
Original Research | By Räber L, Koskinas KC, Yamaji K et al.
OBJECTIVES - This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment. BACKGROUND - OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo...
When, where, and how to target vascular inflammation in the post-CANTOS era?
Editorial | By Maffia P, Guzik TJ.
This editorial refers to ‘Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis’, by A. Vrommanetal., doi:10.1093/eurheartj/ehz008
Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis
Original Research | By Vromman A, Ruvkun V, Shvartz E et al.
AIMS - Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown a prominent role of IL-1α rather than IL-1β in atherosclerosis, or even a deleterious effect of IL-1 on outward arterial remodelling in atherosclerosis-susceptible mice. T...
Systemic microvascular dysfunction in microvascular and vasospastic angina
Original Research | By Ford TJ, Rocchiccioli P, Good R et al.
The spectrum of chronic coronary syndromes: genetics, imaging, and management after PCI and CABG
Updated clinical classification of pulmonary hypertension
Review Article | By Simonneau G, Gatzoulis MA, Adatia I et al.
Novel Transcatheter Mitral Valve Prosthesis for Patients With Severe Mitral Annular Calcification
Original Research | By P Sorajja, M Gössl, V Babaliaros et al.
BACKGROUND - Treatment of mitral regurgitation (MR) in the setting of severe mitral annular calcification (MAC) is challenging due to the high risk for fatal atrioventricular groove disruption and significant paravalvular leak. OBJECTIVES - The objective of this study was to evaluate the potential for transcatheter mitral valve replacement in patients with severe MAC using an anatomically designed mitral pr...