Gender Differences in Transfemoral Transcatheter Aortic Valve Replacement
Original Research | By W Vlastra, J Chandrasekhar, BGD Blanco et al.
BACKGROUND - Transfemoral aortic valve replacement (TAVR) is a guideline-recommended treatment option for patients with severe aortic valve stenosis. Females and males present with different baseline characteristics, which may influence procedural outcomes. OBJECTIVES - To evaluate differences between females and males undergoing transfemoral TAVR across the globe during the last decade. ...
Long-Term Durability of Transcatheter Heart Valves: Insights From Bench Testing to 25 Years
Original Research | By J Sathananthan, M Hensey, U Landes et al.
OBJECTIVES - This study assessed the long-term durability of nominally deployed transcatheter heart valves (THV) to 1 billion cycles (equivalent to 25 years) and non-nominal (overexpansion, underexpansion, and elliptical) THV deployments to 200 million cycles (equivalent to 5 years) with accelerated wear testing. METHODS - SAPIEN 3 THVs, sized 20, 23, 26, and 29 mm were assessed. Nominally deplo...
Clinical Trial | By B Faurie, G Souteyrand, the EASY TAVI investigators.
BACKGROUND - Rapid ventricular pacing is necessary to ensure cardiac standstill during transcatheter aortic valve implantation (TAVI). OBJECTIVES - We investigated whether left ventricular (LV)-stimulation via a guidewire reduced procedure duration while maintaining efficacy and safety compared with standard right ventricular (RV)-stimulation. METHODS - T...
Physiologic Characteristics and Clinical Outcomes of Patients With Discordance Between FFR and iFR
Original Research | By SH Lee, KH Choi, JM Lee et al.
OBJECTIVES - The study evaluated the physiologic characteristics of discordant lesions between instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) and the prognosis at 5 years. BACKGROUND - FFR or iFR have been standard methods for assessing the functional significance of coronary artery stenosis. However, limited data exist about the physiologic characteristics of discordant lesions and ...
Original Research | By N Kogame, K Takahashi, M Tomaniak et al.
OBJECTIVES- The aim of this study was to investigate the impact of post–percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) on clinical outcomes in patients with de novo 3-vessel disease (3VD) treated with contemporary PCI. BACKGROUND- The clinical impact of post-PCI QFR in patients treated with state-of-art PCI for de novo 3VD is undetermined. METHO...
Original Research | By D Aggarwal, M Seth, E Perdoncin et al.
Ticagrelor with or without Aspirin in High-Risk Patients after PCI
Clinical Trial | By R Mehran, U Baber, SK Sharma et al.
BACKGROUND - Monotherapy with a P2Y12 inhibitor after a minimum period of dual antiplatelet therapy is an emerging approach to reduce the risk of bleeding after percutaneous coronary intervention (PCI). METHODS - In a double-blind trial, we examined the effect of ticagrelor alone as compared with ticagrelor plus aspirin with regard to clinically relevant bleeding among patients who were at high ris...
Clinical Trial | By S Windecker , RD Lopes, AUGUSTUS Investigators et al.
Clinical Trial | By Steigen TK, M Maeng, the Nordic PCI Study Group et al.