Incidence and Outcomes of Surgical Bailout During TAVR : Insights From the STS/ACC TVT Registry
Original Research | By AM Pineda, JK Harrison, NS Kleiman et al.
OBJECTIVES - The aim of this study was to evaluate the incidence and outcomes of surgical bailout during transcatheter aortic valve replacement (TAVR). BACKGROUND- The incidence and outcomes of unplanned conversion to open heart surgery, or “surgical bailout,” during TAVR are not well characterized. METHODS- Data from the Society of Thoracic Surgeons/American College of C...
Original Research | By Nassif ME, Windsor S, DEFINE-HF Investigators.
Qualitative Methodology in Cardiovascular Outcomes Research: A Contemporary Look
Review Article | By McIlvennan CK, Morris MA, Guetterman TC et al.
Qualitative and Mixed Methods Provide Unique Contributions to Outcomes Research
From Early Pharmacology to Recent Pharmacology Interventions in Acute Coronary Syndromes
Review Article | By Szummer K, Jernberg T, Wallentin L.
This focus seminar will take the reader through the history and pivotal trials that have formed the current state-of-the-art management for acute coronary syndromes. The identification of a ruptured plaque with thrombus formation and subsequent occlusion or downstream embolization in the coronary artery was the key to developing new and effective treatment strategies. The traditional wait-and-see approach with prolonged bedrest was repl...
From Detecting the Vulnerable Plaque to Managing the Vulnerable Patient
Review Article | By A Arbab-Zadeh, V Fuster.
The past decades have seen tremendous progress on elucidating mechanisms leading to acute coronary syndrome and sudden cardiac death. Pathology and imaging studies have identified features of coronary atherosclerosis that precede acute coronary events. However, many factors influence the risk of adverse events from coronary atherosclerotic disease and available data support our transition from focusing on individual “vulnerable plaque,” coronary arte...
From Focal Lipid Storage to Systemic Inflammation
Review Article | By P Libby, GK Hansson.
Concepts of atherogenesis have evolved considerably with time. Early animal experiments showed that a cholesterol-rich diet could induce fatty lesion formation in arteries. The elucidation of lipoprotein metabolism ultimately led to demonstrating the clinical benefits of lipid lowering. The view of atheromata as bland accumulations of smooth muscle cells that elaborated an extracellular matrix that could entrap lipids then expanded to embrace...
From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events
Review Article | By A Ahmadi, E Argulian, J Leipsic et al.
It has been believed that most acute coronary events result from the rupture of mildly stenotic plaques, based on studies in which angiographic information was available from many months to years before the event. However, serial studies in which angiographic data were available from the past as also within 1 to 3 months of myocardial infarction have clarified that nonobstructive lesions progressively enlarged relatively rapidly before the acute e...
Original Research | By A Bularga, KK Lee, the High-STEACS Investigators et al.