Original Research | By AR van Rosendael, AM Bax, JM Smit et al.
AIMS - In patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent. METHODS AND RESULTS - Patients from the long-term CONFIRM registry without prior CAD and without obstructive (≥50%) stenosis were included. Within the groups of normal coronary computed tomography angiography (CCTA) (N = 1849) and non-ob...
The Use of Sex-Specific Factors in the Assessment of Women’s Cardiovascular Risk
Original Research | By A Agarwala, ED Michos, SS Virani et al.
Cardiovascular disease (CVD) is the leading cause of death among women in the United States. As compared with men, women are less likely to be diagnosed appropriately, receive preventive care, or be treated aggressively for CVD. Sex differences between men and women have allowed for the identification of CVD risk factors and risk markers that are unique to women. The 2018 American Heart Association/American C...
Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association
Universal Definition of Myocardial Infarction
Original Research | By JT Saxon, JA Grantham , AC Salisbury et al.
BACKGROUND - The American College of Cardiology/American Heart Association Appropriate Use Criteria were designed to aid clinical decision-making, yet their association with health status outcomes after chronic total occlusion percutaneous coronary intervention (PCI) is unknown. METHODS - We analyzed 769 patients with baseline and 1-year health status data after chronic total occlusion PCI. P...
Transition of Macrophages to Fibroblast-Like Cells in Healing Myocardial Infarction
Original Research | By N Haider, L Boscá, HR Zandbergen et al.
BACKGROUND - Macrophages and fibroblasts are 2 major cell types involved in healing after myocardial infarction (MI), contributing to myocardial remodeling and fibrosis. Post-MI fibrosis progression is characterized by a decrease in cardiac macrophage content. OBJECTIVES - This study explores the potential of macrophages to express fibroblast genes and the direct role of these cells in post-MI cardiac fibros...
von Willebrand Factor and Management of Heart Valve Disease: JACC Review Topic of the Week
Original Research | By M Mehr, M Taramasso, J Hausleiter et al.
OBJECTIVES - The purpose of this study was to evaluate procedural and 1-year clinical and echocardiographic outcomes of patients treated with tricuspid edge-to-edge repair. BACKGROUND - Transcatheter edge-to-edge repair has been successfully performed in selected patients with symptomatic tricuspid regurgitation (TR) and high risk for surgery, but outcome data are sparse. METHO...
Long-Term Outcomes of Anticoagulation for Bioprosthetic Valve Thrombosis
Original Research | By I Petrescu, AC Egbe, F Ionescu et al.
BACKGROUND - Early in the prevention and treatment of bioprosthetic valve thrombosis (BPVT), anticoagulation is effective, but the long-term outcome after BPVT is unknown. OBJECTIVES - The goal of this study was to assess the long-term outcomes of patients with BPVT treated with anticoagulation. METHODS - This analysis was a matched cohort study of patien...
Original Research | By M Packer, PA Grayburn.
IMPORTANCE - Traditionally, physicians distinguished between mitral regurgitation (MR) as a determinant of outcomes and MR as a biomarker of left-ventricular (LV) dysfunction by designating the lesions as primary or secondary, respectively. In primary MR, leaflet abnormalities cause the MR, resulting in modest increases in LV end-diastolic volume over time, whereas in patients with classic secondary MR, LV dysfunction a...