Original Research | By DJ Angiolillo, D Capodanno, N Danchin et al.
OBJECTIVES - The aim of this study was to develop a risk score integrating cytochrome P450 2C19 loss-of-function genotypes with clinical risk factors influencing clopidogrel response that would allow the identification with more precision of subjects at risk for high platelet reactivity (HPR) and adverse clinical outcomes. BACKGROUND - Clopidogrel is the most broadly used platelet P2Y12 inhibitor. Ho...
Intravascular Ultrasound to Guide Left Main Stem Intervention: A Sub-Study of the NOBLE Trial
Original Research | By A Ladwiniec, SJ Walsh, EH Christiansen et al.
Original Research | By T Ochiai, T Chakravarty, SH Yoon et al.
OBJECTIVES - The aim of this study was to assess the incidence of unfavorable coronary access after transcatheter aortic valve replacement (TAVR) using post-implantation computed tomography (CT). BACKGROUND - Real-world data regarding coronary access after TAVR assessed using post-implantation CT are scarce. METHODS - Post-TAVR CT of 6...
Coronary Access After TAVR With a Self-Expanding Bioprosthesis: Insights From Computed Tomography
Original Research | By M Abdelghani, M Landt, H Traboulsi et al.
OBJECTIVES - The authors sought to estimate possible interference of the Medtronic Evolut R/Pro transcatheter heart valve (THV) frame with coronary access using multislice computed tomography (MSCT) data. BACKGROUND - Lower-risk patients undergoing transcatheter aortic valve replacement (TAVR) endure a high cumulative risk of coronary events, but coronary access can be challenging. ...
Feasibility of Coronary Access and Aortic Valve Reintervention in Low-Risk TAVR Patients
Original Research | By T Rogers, BC Greenspun, G Weissman et al.
OBJECTIVES - The aim of this study was to evaluate the feasibility of coronary access and aortic valve reintervention in low-risk patients undergoing transcatheter aortic valve replacement (TAVR) with a balloon-expandable transcatheter heart valve (THV). BACKGROUND - Younger, low-risk TAVR patients are more likely than older, higher risk patients to require coronary angiography, percutaneous co...
Original Research | By T Palmerini, T Chakravarty, F Saia et al.
OBJECTIVES - The aim of this study was to investigate the safety and efficacy of coronary protection by preventive coronary wiring and stenting across the coronary ostia in patients at high risk for coronary obstruction after transcatheter aortic valve replacement (TAVR). BACKGROUND - Coronary obstruction following TAVR is a life-threatening complication with high procedural and short-term morta...
Select Drug-Drug Interactions With Direct Oral Anticoagulants
Review Article | By BS Wiggins, DL Dixon, RR Neyens et al.
Millions of individuals in the United States require long-term treatment with an oral anticoagulant. For decades, vitamin K antagonists were the only oral option available; however, they have a number of well-known limitations. Introduction of the direct oral anticoagulants (DOACs) has long been considered a major therapeutic advance, largely because they lack the need for therapeutic monitoring. Despite this, DOACs, like...
Original Research | By SP Schumacher; H Everaars; WJ Stuijfzand et al.
Original Research | By JN Li, LJ Zhang, Y He et al.
OBJECTIVE - Late gadolinium enhancement(LGE) cardiac magnetic resonance imaging(CMR) was used to evaluate the myocardial viability of chronic total occlusion(CTO) in patients with coronary heart disease and to observe the relationship between collateral circulation and myocardium viability in these patients. METHODS - This retrospective study included 40 patients with CTO diagnosed by invasive coronary a...
Contrast-Associated Acute Kidney Injury and Serious Adverse Outcomes Following Angiography
Original Research | By SD Weisbord, PM Palevsky, the PRESERVE Trial Investigators et al.
BACKGROUND - Contrast-associated acute kidney injury (CA-AKI) associates with an increased relative risk for serious adverse outcomes. However, the magnitude of this risk and the incidence of clinically significant CA-AKI derived from analyses of large cohorts with prospective assessment of CA-AKI and subsequent outcomes are unknown. OBJECTIVES - This study sought to char...