Survival After Coronary Revascularization With Paclitaxel-Coated Balloons
Review Article | By B Scheller, D Vukadinovic, R Jeger et al.
BACKGROUND - Drug-coated balloons (DCBs) are accepted treatment strategies for coronary in-stent restenosis and are under clinical investigation for lesions without prior stent implantation. A recently published meta-analysis suggested an increased risk of death associated with the use of paclitaxel-coated devices in the superficial femoral artery. The reasons are incompletely understood as potential underlying pathomechanisms remai...
Original Research | By M Mehr, J Hausleiter and for the TriValve and TRAMI Investigators.
OBJECTIVES - The aim of this study was to retrospectively compare the characteristics, procedural courses, and outcomes of patients presenting with concomitant mitral regurgitation (MR) and tricuspid regurgitation (TR) in the TriValve (Transcatheter Tricuspid Valve Therapies) and TRAMI (Transcatheter Mitral Valve Interventions) registries. BACKGROUND - Transcatheter mitral edge-to...
Outcomes of TTVI in Patients With Pacemaker or Defibrillator Leads: Data From the TriValve Registry
Original Research | By M Taramasso, M Gavazzoni, A Pozzoli et al.
OBJECTIVES - The interference of a transtricuspid cardiac implantable electronic device (CIED) lead with tricuspid valve function may contribute to the mechanism of tricuspid regurgitation (TR) and poses specific therapeutic challenges during transcatheter tricuspid valve intervention (TTVI). Feasibility and efficacy of TTVI in presence of a CIED is unclear. BACKGROUND - Feasibility of TTVI in pres...
Original Research | By BM Scirica, BA Bergmark, DA Morrow et al.
BACKGROUND - Recent emphasis on reduced duration and/or intensity of antiplatelet therapy following percutaneous coronary intervention (PCI) irrespective of indication for PCI may fail to account for the substantial risk of subsequent nontarget lesion events in acute coronary syndrome (ACS) patients. OBJECTIVES - The authors sought to examine the effect of more potent antiplatelet therapy on the basis of the ti...
Clinical Trial | By SP Marso, FMM Baeres, and on behalf of the LEADER Trial Investigators.
BACKGROUND - More data regarding effects of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes (T2D) and heart failure (HF) are required. OBJECTIVES - The purpose of this study was to investigate the effects of liraglutide on cardiovascular events and mortality in LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) p...
Original Research | By Y Fan, XJ Guo, LS Wang et al.
BACKGROUND - In mammalian, regenerative therapy after myocardial infarction (MI) is hampered by the limited regenerative capacity of adult heart, while a transient regenerative capacity is maintained in the neonatal heart. Systemic phosphorylation signaling analysis on ischemic neonatal myocardium might be helpful to identify key pathways involved in heart regeneration. We aimed to define kinase-substrate network in ischem...
Diuretic Therapy for Patients With Heart Failure: JACC State-of-the-Art Review
Review Article | By GM Felker, DH Ellison, W Mullens et al.
Expansion of extracellular fluid volume is central to the pathophysiology of heart failure. Increased extracellular fluid leads to elevated intracardiac filling pressures, resulting in a constellation of signs and symptoms of heart failure referred to as congestion. Loop diuretics are one of the cornerstones of treatments for heart failure, but in contrast to other therapies, robust clinical trial evidence to guide the use of diuretics is sparse. A nuanc...
Early Diagnosis of Myocardial Infarction With Point-of-Care High-Sensitivity Cardiac Troponin I
Original Research | By J Boeddinghaus, T Nestelberger, and for the APACE Investigators et al.
Clinical Trial | By F Leclercq, P Robert, M Akodad et al.
OBJECTIVES - The aim of this study was to evaluate device success of transcatheter aortic valve replacement (TAVR) using new-generation balloon-expandable prostheses with or without balloon aortic valvuloplasty (BAV). BACKGROUND - Randomized studies are lacking comparing TAVR without BAV against the conventional technique of TAVR with BAV. METHO...
Original Research | By A Kawsara, F Alqahtani, MF Eleid et al.
OBJECTIVES - This study sought to use a national representative database to assess the incidence, predictors, and outcomes of balloon aortic valvuloplasty (BAV) as a bridge to transcatheter aortic valve replacement (TAVR) in contemporary practice. BACKGROUND - Nationwide data on the use and outcomes of BAV as a bridge to TAVR are limited. METHODS -...