Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study
Clinical Trial | By DJ Angiolillo, U Baber, R Mehran et al.
BACKGROUND - P2Y12 inhibitor monotherapy with ticagrelor after a brief period of dual antiplatelet therapy can reduce bleeding without increasing ischemic harm after percutaneous coronary intervention (PCI). The impact of this approach among patients with diabetes mellitus (DM) remains unknown. OBJECTIVES - The purpose of this study was to examine the effect of ticagrelor monotherapy versus ticagrelo...
Ticagrelor With or Without Aspirin After Complex PCI
Clinical Trial | By G Dangas, U Baber, R Mehran et al.
BACKGROUND - Whether a regimen of ticagrelor monotherapy attenuates bleeding complications without increasing ischemic risk in patients undergoing complex percutaneous coronary intervention (PCI) is unknown. OBJECTIVES - The purpose of this study was to evaluate the effect of ticagrelor monotherapy versus ticagrelor plus aspirin in patients undergoing complex PCI from the randomized, double-blind, placebo...
Clinical Trial | By B Scheller, MA Ohlow, S Ewen et al.
AIMS - Drug-coated balloons (DCB) may avoid stent-associated long-term complications. This trial compared the clinical outcomes of patients with non-ST-elevation myocardial infarction (NSTEMI) treated with either DCB or stents. METHODS AND RESULTS - A total of 210 patients with NSTEMI were enrolled in a randomised, controlled, non-inferiority multicentre trial comparing a pacl...
Consensus | By PB Shah, FGP Welt, E Mahmud et al.
The COVID-19 pandemic has strained health care resources around the world causing many institutions to curtail or stop elective procedures. This has resulted in the inability to care for patients valvular and structural heart disease (SHD) in a timely fashion potentially placing these patients at increased risk for adverse cardiovascular complications including congestive heart failure and death. The effective triage of these patients has become...
Original Research | By KF Dou, D Zhang, the CIT-RESOLVE Investigators et al.
OBJECTIVES - The aim of this study was to determine whether an active side branch protection (SB-P) strategy is superior to the conventional strategy in reducing side branch (SB) occlusion in high-risk bifurcation treatment. BACKGROUND - Accurate prediction of SB occlusion after main vessel stenting followed by the use of specific strategies to prevent occlusion would be beneficial during bifurcation interventio...
Clinical Trial | By U Baber, R Chandiramani, R Mehran et al.
BACKGROUND - Data examining the safety and efficacy of the bioabsorbable polymer (BP) drug‐eluting stent (DES) as compared with durable polymer (DP) DES in high‐risk patients undergoing percutaneous coronary intervention (PCI) remain limited. METHODS - We conducted a pre‐specified analysis among patients enrolled in the TWILIGHT trial treated with the SYNERGY BP‐DES or a ...
Physiological Stratification of Patients With Angina Due to Coronary Microvascular Dysfunction