Lipid-Modifying Agents, From Statins to PCSK9 Inhibitors: JACC Focus Seminar
Review Article | By D Preiss, JA Tobert, GK Hovingh et al.
Mendelian randomization studies and randomized trials have conclusively demonstrated that lower low-density lipoprotein (LDL) cholesterol results in fewer cardiovascular events. This review describes key stages in the evolution of LDL cholesterol–lowering treatment. Data from over 25 cardiovascular outcome trials confirm that, within a few years, statins lower the relative risk of major atherosclerotic events by about 22% per 38.7&nb...
Optimal Timing of Intervention in NSTE-ACS Without Pre-Treatment The EARLY Randomized Trial
Original Research | By G Lemesle, M Laine, M Pankert et al.
OBJECTIVES - The aim of this study was to compare a delayed and a very early invasive strategy in patients with non–ST-segment elevation acute coronary syndromes (NSTE-ACS) without pre-treatment. BACKGROUND - The optimal delay of the invasive strategy in patients with NSTE-ACS remains debated and has never been investigated in patients not pre-treated with P2Y12–adenos...
Incidence and Outcomes of Acute Coronary Syndrome After Transcatheter Aortic Valve Replacement
Original Research | By AMentias, MY Desai, M Saad et al.
OBJECTIVES - This study sought to address a knowledge gap by examining the incidence, timing, and predictors of acute coronary syndrome (ACS) after transcatheter aortic valve replacement (TAVR) in Medicare beneficiaries. BACKGROUND - Evidence about incidence and outcomes of ACS after TAVR is scarce. METHODS - We identified medicare patient...
The Natural History of Nonculprit Lesions in STEMI: An FFR Substudy of the Compare-Acute Trial
Original Research | By Z Piróth, BM B-de Klerk, E Omerovic et al.
OBJECTIVES - The aim of this study was to determine the prognostic value of fractional flow reserve (FFR) in non-infarct-related arteries (IRAs) in ST-segment elevation myocardial infarction (MI). BACKGROUND - Patients with ST-segment elevation MI often present with multivessel disease. The treatment of non-IRAs is debated. The applicability of FFR has not been widely pr...
Original Research | By B Shahim, B Redfors, S Chen et al.
OBJECTIVES - The aim of this study was to examine the association between body mass index (BMI), infarct size (IS) and clinical outcomes. BACKGROUND - The association between obesity, IS, and prognosis in patients undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction is incompletely understood. METHODS&n...
Original Research | By AMK Rothman, J-L Vachiery, LS Howard et al.
Original Research | By M Mancone, R Cavalcante, PW Serruys et al.
Major infections after bypass surgery and stenting: an overlooked but fatal complication
Original Research | By GG Toth, V Sasi; D Franco et al.
AIMS - To assess, whether Culotte technique could be improved by an additional kissing dilation prior main branch (MB) stenting. METHODS AND RESULTS - Double-kissing (DK) Culotte was compared to Culotte and DK-Crush techniques in bench model (n=24). Results were evaluated for stent apposition, for luminal opening and for flow dynamics.Total procedure duration of DK-Culotte was 18.3±3.4...
Pulmonary Hypertension Caused by a Coconut Left Atrium
Clinical Case Study | By EC Leung, N Hirani et al.
“Coconut atrium” was first described in 1898 and is most commonly associated with rheumatic heart disease. This case demonstrates a dramatic chest x-ray image of extensive circumferential calcification of the left atrium. The abnormality was thought to result in elevated pulmonary pressures and severe right heart failure in the absence of significant mitral valve dysfunction.