Original Research | By H Gonzales, PS Douglas, BR Lindman et al.
OBJECTIVES - This study sought to evaluate the association between severity of left ventricular hypertrophy (LVH) before transcatheter aortic valve replacement (TAVR) and outcomes out to 5 years. BACKGROUND - Prior studies assessing the association between baseline LVH and outcomes after surgical or TAVR for aortic stenosis (AS) have yielded conflicting results. MET...
Original Research | By Sicong Ma, Zaixin Jiang, YL Han et al.
INTRODUCTION - Optimal dual antiplatelet therapy (DAPT) duration for medically managed acute coronary syndrome (ACS) (MMACS) patients is still unknown. We explored the efficacy and safety of ≥ 12-month DAPT among MMACS patients. METHODS - In this sub-analysis of the optimal antiplatelet therapy for Chinese Patients with Coronary Artery Disease study (NCT01735305), clinical outcomes a...
Original Research | By J Sathananthan, P Green, M Finn et al.
BACKGROUND - While slow gait speed is known to be associated with poor outcomes in patients at high surgical risk who undergo transcatheter aortic valve replacement (TAVR), the prognostic significance of slow gait speed in intermediate risk TAVR patients is poorly understood. OBJECTIVES - We assessed the association between baseline 6‐min walk test (6MWT) performance and both 2‐year mortality and healt...
Original Research | By Neel M. Butala, Mabel Chung, Eric A. Secemsky
OBJECTIVES - The aims of this study were to examine variation in the use of conscious sedation (CS) for transcatheter aortic valve replacement (TAVR) across hospitals and over time and to evaluate outcomes of CS compared with general anesthesia (GA) using instrumental variable analysis, a quasi-experimental method to control for unmeasured confounding. BACKGROUND - Despite increasing use of CS for...
Original Research | By H Othman, M Seth on behalf of the BMC2 Investigators.
Review Article | By TI Repanas, CA Papanastasiou, TD Karamitsos et al.
Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death: A Review
Review Article | By L Muthukumar, A Jahangir, MF Jan et al.
IMPORTANCE - Malignant arrhythmic mitral valve prolapse (MVP) phenotype poses a substantial risk of sudden cardiac death (SCD), and an estimated 26 000 individuals in the United States are at risk of SCD per year. Thus, identifying risk-stratification strategies for SCD is imperative. OBSERVATIONS - Patients with MVP have a heterogenous clinical spectrum, ranging from a benign course...
Review Article | By RA Ferraro, AR van Rosendael, FY Lin et al.
AIMS - High-risk plaque (HRP) and non-obstructive coronary artery disease independently predict adverse events, but their importance to future culprit lesions has not been resolved. We sought to determine in patients prior to confirmed acute coronary syndrome (ACS) the association between lesion percent diameter stenosis (%DS), and the absolute number and prevalence of HRP. The secondary objective was to examine the relative impo...
Initial Invasive or Conservative Strategy for Stable Coronary Disease
Clinical Trial | By DJ Maron, JS Hochman and for the ISCHEMIA Research Group.
BACKGROUND - Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS- We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and m...