Infective Endocarditis After Transcatheter Aortic Valve Replacement
Original Research | By S Stortecky, D Heg, D Tueller, T Pilgrim et al.
BACKGROUND - Infective endocarditis may affect patients after transcatheter aortic valve replacement (TAVR). OBJECTIVES - The purpose of this study was to provide detailed information on incidence rates, types of microorganisms, and outcomes of infective endocarditis after TAVR. METHODS - Between February 2011 and July 2018, consecutive patients from the SwissTAV...
Original Research | By H Park, J-M Ahn,S-J Park et al.
OBJECTIVES - This study compared the 3-year outcomes of intracoronary imaging–guided pre-dilation, stent sizing, and post-dilation (iPSP) for patients with complex coronary artery lesions. BACKGROUND - The long-term effects of the optimal drug-eluting stent implantation technique in complex coronary artery disease have not been evaluated. METHODS - From the IRIS-D...
Coronary Calcification and Long-Term Outcomes According to Drug-Eluting Stent Generation
Original Research | By P Guedeney, BE Claessen, GW Stone et al.
OBJECTIVES - The aim of this study was to evaluate the long-term impact of coronary artery calcification (CAC) on outcomes after percutaneous coronary intervention and the respective performance of first- and second-generation drug-eluting stents (DES). BACKGROUND - Whether contemporary DES have improved the long-term prognosis after percutaneous coronary intervention in lesions with severe C...
Review Article | By GDI Gioia, J Sonck, C Collet et al.
OBJECTIVES - The aim of this study was to compare clinical outcomes of different bifurcation percutaneous coronary intervention (PCI) techniques. BACKGROUND - Despite several randomized trials, the optimal PCI technique for bifurcation lesions remains a matter of debate. Provisional stenting has been recommended as the default technique for most bifurcation lesions. Emerging data support double-kissing crush ...
Original Research | By MC Baker, YJ Weng, RH William et al.
OBJECTIVE - Osteoarthritis (OA) is a common cause of joint pain and disability, and effective treatments are lacking. Extracellular adenosine has anti-inflammatory effects and can prevent and treat OA in animal models. Ticagrelor and clopidogrel are both used in patients with coronary artery disease, but only ticagrelor increases extracellular adenosine. The aim of this study was to determine whether treatment with ticagrelor was as...
Original Research | By MP Winter, PE Bartko, G Goliasch et al.
AIMS - Concomitant secondary atrioventricular regurgitation is frequent in patients with severe aortic stenosis scheduled for transcatheter aortic valve replacement (TAVR). The future implications of leaving associated valve lesions untreated after TAVR remain unknown. Aim of the present study was to characterize the evolution of concomitant secondary atrioventricular regurgitations and to evaluate their impact on long-term prognosis. &...
Review Article | By CJ Kapelios, Μ Bonou, K Malliaras et al.
There is ongoing controversy regarding the association between loop diuretics (LD), especially in high doses, and adverse clinical outcomes in outpatients with heart failure (HF). We performed a systematic review of the evidence for LD in outpatients with HF. We searched MEDLINE, EMBASE, and Cochrane Clinical Trial Collection to identify controlled studies, evaluating the association between LD and morbidity a...
The Management of Atrial Fibrillation in Heart Failure: An Expert Panel Consensus
Review Article | By D Farmakis, C Chrysohoou, G Giamouzis et al.
Heart failure (HF) and atrial fibrillation (AF) often coexist, being closely interrelated as the one increases the prevalence and incidence and worsens the prognosis of the other. Their frequent coexistence raises several challenges, including under-diagnosis of HF with preserved ejection fraction in AF and of AF in HF, characterization and diagnosis of atrial cardiomyopathy, target and impact of rate control therapy on outcomes, optimal rhy...
Original Research | By JJ Zhang, F Ye, Kai Xu et al.
AIM - The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. METHODS AND RESULTS - In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint w...
Clinical Trial | By B-K Kim, S-J Hong, TICO Investigators et al.
IMPORTANCE - Discontinuing aspirin after short-term dual antiplatelet therapy (DAPT) was evaluated as a bleeding reduction strategy. However, the strategy of ticagrelor monotherapy has not been exclusively evaluated in patients with acute coronary syndromes (ACS). OBJECTIVE - To determine whether switching to ticagrelor monotherapy after 3 months of DAPT reduces net adverse clinical events compared with...