Transcatheter and surgical aortic valve replacement in patients with bicuspid aortic valve
Original Research | By E Ajufo, CR Ayers, R Vigen et al.
IMPORTANCE - Higher coronary artery calcium (CAC) identifies individuals at increased atherosclerotic cardiovascular disease (ASCVD) risk. Whether it can also identify individuals likely to derive net benefit from aspirin therapy is unclear. OBJECTIVE - To examine the association between CAC, bleeding, and ASCVD and explore the net estimated effect of aspirin at different CAC thresholds. D...
Original Research | By D Zanetti , S Gustafsson, E Ingelsson et al.
BACKGROUND - Circulating biomarkers have been previously associated with atherosclerosis related risk factors, but the nature of these associations is incompletely understood. METHODS - We performed multivariable-adjusted regressions and two-sample Mendelian randomization (MR) analyses to assess observational and causal associations of 27 circulating biomarkers with 7 cardiovascular traits in up to 451...
Dilated cardiomyopathy: so many cardiomyopathies!
Expert Opinion | By G Sinagra, PM Elliott, M Merlo et al.
The current definition of dilated cardiomyopathy (DCM) is relatively simple; namely, a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient to explain the dysfunction.1 In the last decades, the prognosis of patients with DCM has improved significantly with survival free from death and heart transpla...
Original Research | By K Sliwa, MC Petrie, P van der Meer et al.
Original Research | By ME Farkouh , LC Godoy, V Fuster et al.
Clinical Trial | By WJ Jang, JB Lee, YB Song et al.
AIMS - We sought to compare biodegradable-polymer biolimus-eluting stents(BP-BES) with durable-polymer everolimus-eluting(DP-EES) and zotarolimus-eluting stents(DP-ZES) in patients with acute coronary syndrome(ACS) according to different duration of dual antiplatelet therapy(DAPT). METHODS AND RESULTS - In the SMART-DATE trial, 2712 patients with ACS underwent randomization for allo...
Original Research | By B Tamarappoo, D Han, D Berman et al.
OBJECTIVES - The association between extracellular volume (ECV) measured by computed tomography angiography (CTA) and clinical outcomes was evaluated in low-flow low-gradient (LFLG) aortic stenosis (AS) patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND - Patients with LFLG AS comprise a high-risk group with respect to clinical outcomes. Although ECV...
Extracellular Myocardial Volume in Patients With Aortic Stenosis
Original Research | By RJ Everett , TA Treibel , M Fukui et al.