Original Research | By JA Doll , RS Hira , KE Kearney et al.
Complications of percutaneous coronary intervention (PCI) may have significant impact on patient survival and healthcare costs. PCI procedural complexity and patient risk are increasing, and operators must be prepared to recognize and treat complications, such as perforations, dissections, hemodynamic collapse, no-reflow, and entrapped equipment. Unfortunately, few resources exist to train operators in PCI complication management. Uncerta...
Procedural and Short-Term Results With the New Watchman FLX Left Atrial Appendage Occlusion Device
Original Research | By Ignacio Cruz-Gonzalez 1 , Kasper Korsholm 2 , Blanca Trejo-Velasco
OBJECTIVES - This study sought to report early experience with the new-generation Watchman FLX device (Boston Scientific, Marlborough, Massachusetts). BACKGROUND - The new-generation Watchman FLX features a reduced height, improved anchoring and fabric coverage, and a closed distal end. These design modifications aim to simplify implantation, allow full recapture and repositioning, and reduce peridevice leak and ...
Chimney technique in a TAVR-in-TAVR procedure with high risk of left main artery ostium occlusion
Clinical Case Study | By A Dibie, Q Landolff, A Veugeois et al.
An 87-year-old woman was referred to our centre for a valve-in-valve transcatheter aortic valve replacement (TAVR). She underwent a TAVR procedure with implantation of a SAPIEN XT 26 mm (Edwards Lifesciences) bioprosthesis 7 years before but subsequently developed symptomatic aortic valve failure (mean gradient = 64 mmHg). Pre-procedural computed tomography (CT) scan identified a low height between the valvular...
Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization
Clinical Trial | By K Oyama, RHM Furtado, BA Bergmark et al.
BACKGROUND - Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors induce plaque regression and reduce the risk of coronary revascularization overall. OBJECTIVES - To evaluate the ability of PCSK9 inhibitors to reduce the risk of complex coronary atherosclerosis requiring revascularization. METHODS - FOURIER was a randomized trial of the PCSK9 inhibitor evolocum...
Clinical Trial | By J Silvain, B Lattuca, ALPHEUS investigators et al.
Original Research | By M Fedchenko, Z Mandalenakis, KW Giang et al.
Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy
Clinical Trial | By P Thavendiranathan, T Negishi, SUCCOUR investigators et al.
BACKGROUND - In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardio-protective therapy (CPT) is constrained by the low sensitivity of EF for minor changes in LV function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine GLS-guided strategy for CPT. OBJECTIV...
Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction
Clinical Trial | By TJ Ford, D Corcoran, S Padmanabhan et al.