Why NOBLE and EXCEL Are Consistent With Each Other and With Previous Trials
Expert Opinion | By Gersh BJ, Stone GW, Bhatt DL et al.
Approximately 60 randomized controlled trials performed over the last 3 decades have failed to demonstrate statistically significant differences in death or myocardial infarction (MI) between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), apart from a few notable exceptions in which CABG was superior to PCI. The benefits for CABG have been reported in patients with diabetes mellitus with multivessel dis...
Treatment of coronary bifurcation lesions: current knowledge and future perspectives
Review Article | By Elwany M, Palma GD, Cortese B et al.
Coronary lesions at bifurcation sites are frequent and still remain a challenging subset for the interventional cardiologist. Although in the last years the provisional stenting technique has shown more consistent results, coronary bifurcation interventions still share a worse procedural success rate and increased rates of mid- and long-term cardiac events. Most of the dedicated devices proposed in the last few years have failed to show improved resul...
Exercise Therapy and Cardiovascular Toxicity in Cancer
Review Article | By Scott JM, Nilsen TS, Gupta D et al.
Cardio-oncology is an emerging discipline focused predominantly on the detection and management of cancer treatment-induced cardiac dysfunction (cardiotoxicity), which predisposes to development of overt heart failure or coronary artery disease. The direct adverse consequences, as well as those secondary to anticancer therapeutics, extend beyond the heart, however, to affect the entire cardiovascular-skeletal muscle axis (ie, whole-organism cardiovas...
Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis
Review Article | By Waxman AJ, Clasen S, Hwang WT et al.
IMPORTANCE - Cardiovascular adverse events (CVAE) with carfilzomib in patients with multiple myeloma can be potentially life-threatening and remain incompletely characterized. We performed the first systematic review and meta-analysis of carfilzomib-associated CVAE. OBJECTIVE - To determine the incidence of carfilzomib-associated CVAE and to compare the rates of carfilzomib CVAE among...
Review Article | By Porta-Sánchez A, Gilbert C, Thavendiranathan P et al.
BACKGROUND - The cardiovascular complications of cancer therapeutics are the focus of the burgeoning field of cardio-oncology. A common challenge in this field is the impact of cancer drugs on cardiac repolarization (ie, QT prolongation) and the potential risk for the life-threatening arrhythmia torsades de pointes. Although QT prolongation is not a perfect marker of arrhythmia risk, this has become a primary safety metric among oncolog...
Original Research | By Mangla A, Doukky R, Powell LH et al.
BACKGROUND - Socioeconomically disadvantaged patients are at an increased risk for adverse heart failure (HF) outcomes based upon nonadherence to medications and diet. Physicians are also suboptimally adherent to prescribing evidence-based therapy for HF. METHODS - Congestive Heart Failure Adherence Redesign Trial (CHART) (NCT01698242) is a multicenter, bilevel, cluster randomized behavioral efficacy trial ...
Original Research | By Wong YTA, Kang DY, Park DW et al.
BACKGROUND - This study sought to evaluate the optimal treatment for in-stent restenosis (ISR) of drug-eluting stents (DESs). METHODS - This is a prospective, multicenter, open-label, randomized study comparing the use of drug-eluting balloon (DEB) versus second-generation everolimus-eluting stent for the treatment of DES ISR. The primary end point was in-segment late loss at 9-month routine angiographi...
Clinical Trial | By Park J, Lee JM, Koo BK et al.
BACKGROUND - Understanding of the risk conferred by functionally insignificant lesions in multiple coronary vessels is limited. We investigated the prognostic implications of coronary artery disease (CAD) based on 3-vessel fractional flow reserve (FFR). METHODS AND RESULTS - A total of 1,136 patients underwent FFR measurement in the 3 major epicardial arteries. We defined vessels with "Mo...
Original Research | By Nakamori S, Sakuma H, Dohi K et al.
BACKGROUND - Recent studies using stress-rest perfusion cardiovascular magnetic resonance (CMR) demonstrated a close correlation between myocardial ischemia and reduced fractional flow reserve (FFR). However, its diagnostic concordance may be reduced in patients with multivessel disease. We sought to evaluate the concordance of adenosine stress-rest perfusion CMR for predicting reduced FFR, and to determine the additive va...