Original Research | By Seike F, Uetani T, Nishimura K et al.
BACKGROUND - Fractional flow reserve (FFR) is widely used for the assessment of myocardial ischemia. Intravascular ultrasound (IVUS) is an intracoronary imaging method that provides information about lumen and vessel morphology. Previous studies on the expanded use of IVUS to identify functional ischemia have noted an association between anatomy and physiology, but IVUS-derived minimum lumen area (MLA) has a weak-moder...
Diagnostic Performance of the Instantaneous Wave-Free Ratio: Comparison With Fractional Flow Reserve
Original Research | By De Rosa S, Polimeni A, Indolfi C et al.
BACKGROUND - Aim of the present study was to perform a meta-analysis of all available studies comparing the instantaneous wave-free ratio (iFR) with fractional flow reserve (FFR). METHODS AND RESULTS - Published trials comparing the iFR with FFR were searched for in PubMed, Google Scholar, and Scopus electronic databases. A total of 23 studies were available for the analysis,...
Coronary Computed Tomography–Based Fractional Flow Reserve A Rapidly Developing Field
Review Article | By Baumann S, Renker M, Schoepf UJ.
Coronary computed tomography angiography (cCTA)–based fractional flow reserve (FFR-CT) is an evolving technology of disruptive potential to noninvasively determine the hemodynamic significance of a coronary artery stenosis. The systematic review by Cook et alprovides an excellent overview on the status of this innovative method. In their Methods section, the authors mention the FFR-CT algorithm approved by the US Food and Drug Ad...
Clinical Case Study | By Donnelly PM, Kolossváry M, Maurovich-Horvat P et al.
Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) is a new technique for the diagnosis of ischemic coronary artery stenoses. The aim of this prospective study was to evaluate the diagnostic performance of a novel on-site computed tomography-based fractional flow reserve algorithm (CT-FFR) compared with invasive FFR as the gold standard, and to determine whether its diagnostic performance is...
Clinical Trial | By Lee JM, Koo BK, Shin ES et al.
AIMS - There are limited data on the clinical implications of total physiologic atherosclerotic burden assessed by invasive physiologic studies in patients with coronary artery disease. We investigated the prognostic implications of total physiologic atherosclerotic burden assessed by total sum of fractional flow reserve (FFR) in three vessels (3V-FFR). METHODS AND RESULTS - A total of 1136 patie...
Review Article | By Rutsch M, Akin I, Borggrefe M et al.
We have read with great interest the study by Donnelly et al. published in the online ahead-of-print issue of the American Journal of Cardiology, where the authors investigated the diagnostic performance of a novel, on-site coronary computed tomography-derived fractional flow reserve (CT-FFR) algorithm for the assessment of intermediate coronary stenoses.
Diagnostic Accuracy of Computed Tomography-Derived Fractional Flow Reserve : A Systematic Review
Review Article | By Cook CM, Petraco R, Shun-Shin MJ et al.
IMPORTANCE - Computed tomography-derived fractional flow reserve (FFR-CT) is a novel, noninvasive test for myocardial ischemia. Clinicians using FFR-CT must be able to interpret individual FFR-CT results to determine subsequent patient care. OBJECTIVE - To provide clinicians a means of interpreting individual FFR-CT results with respect to the range of invasive FFRs that this interpretation might ...
Intravascular imaging in coronary artery disease
Review Article | By Mintz GS, Guagliumi G.
Although it is the method used by most interventional cardiologists to assess the severity of coronary artery disease and guide treatment, coronary angiography has many known limitations, particularly the fact that it is a lumenogram depicting foreshortened, shadowgraph, planar projections of the contrast-filled lumen rather than imaging the diseased vessel itself. Intravascular imaging-intravascular ultrasound and more recently optical cohere...
Original Research | By Head SJ, Milojevic M, Daemen J et al.
BACKGROUND - Numerous randomised trials have compared coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) for patients with coronary artery disease. However, no studies have been powered to detect a difference in mortality between the revascularisation strategies. METHODS - We did a systematic review up to July 19, 2017, to identify randomised clinical trials comparing CAB...
Clinical Trial | By Varenne O, Cook S, SENIOR investigators et al.
BACKGROUND - Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration of DAPT in such patients. METHODS -In this randomised single-blind trial, we recruited patients from 44 centres in nine cou...