Original Research | By Bermejo J, Yotti R, SIOVAC investigators et al.
AIMS - We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD). METHODS AND RESULTS - The sildenafil for improving outcomes after valvular correction (SIOVAC) study was a multricentric, randomized, parallel, and placebo-controlled trial that enrolled stable adults with mean pulmon...
Dual antiplatelet therapy: how, how long, and in which patients?
Original Research | By Lüscher TF.
Thrombus formation is a crucial event in acute coronary syndromes, bypass occlusion, and stent thrombosis. In the coronary circulation, platelet activation is an initial event,while expression of tissue factor and subsequent activation of the coagulation cascade and invading white blood cells solidify the evolving clot, an event that often leads to vascular occlusion. Platelets are primarily activated by thromboxane and ADP via thromboxane and P2Y...
Original Research | By Scholz KH, Maier SKG, Maier LS et al.
AIMS - The aim of this study was to investigate the effect of contact-to-balloon time on mortality in ST-segment elevation myocardial infarction (STEMI) patients with and without haemodynamic instability. METHODS AND RESULTS - Using data from the prospective, multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial, we assessed the progn...
Original Research | By Maniwa N, Fujino M, Nakai M et al.
AIMS - There are limited data about the optimal anti-thrombotic therapy for preventing embolism while minimizing bleeding events in patients with first acute myocardial infarction (AMI) complicated by left ventricular thrombus (LVT). METHODS AND RESULTS - Among 2301 consecutive patients with AMI hospitalized between 2001 and 2014, we studied 1850 patients with first AMI who discharged alive to investi...
Original Research | By Shlofmitz E; Matsumura M; Mintz GS et al.
BACKGROUND - As the LAD supplies almost half of the myocardium, the proximal LAD (PLAD) should rarely be small. Given the prognostic significance of both the PLAD and minimal stent area, we evaluated PLAD sizes by IVUS. METHODS - From isolated review of the angiograms from 147 pts who underwent IVUS-guided stenting of de novo PLAD lesions, 4 interventional cardiologists (two of whom were...
Original Research | By Sugiyama T, Yamamoto E, Bryniarski K et al.
IMPORTANCE - Patients with culprit plaque rupture are known to have pancoronary plaque vulnerability. However, the characteristics of nonculprit plaques in patients with acute coronary syndromes caused by plaque erosion are unknown. OBJECTIVE - To investigate the nonculprit plaque phenotype in patients with acute coronary syndrome according to culprit plaque pathology (erosion vs rupture) by 3-vessel optical coherence ...
Patient selection and percutaneous technique of unprotected left main revascularization
Review Article | By Testa L, Latib A, Bollati M et al.
Increasing evidence suggests that percutaneous coronary intervention with newer generation drug-eluting stents may be an acceptable alternative, or even preferred in selected cases to the surgical approach, in patients with left main disease. This review will discuss the anatomic factors, the clinical variables, and the procedural strategies to consider, including physiology assessment and imaging guidance, in order to optimize outcomes.
Therapeutic Options for In-Stent Restenosis
Review Article | By Nicolais C, Lakhter V, Chatterjee S et al.
PURPOSE OF REVIEW - In-stent restenosis (ISR) is a complex disease process that became apparent shortly after the introduction of stents into clinical practice. This review seeks to define in-stent restenosis (ISR) as well as to summarize the major treatment options that have been developed and studied over the past two decades. RECENT FINDINGS - Recent developments in drug-coated balloons and bioresorbab...
Review Article | By Siontis GC, Stefanini GG, Windecker S et al.
BACKGROUND - Percutaneous coronary intervention (PCI) with drug-eluting stents is the standard of care for treatment of native coronary artery stenoses, but optimum treatment strategies for bare metal stent and drug-eluting stent in-stent restenosis (ISR) have not been established. We aimed to compare and rank percutaneous treatment strategies for ISR. METHODS - We did a network meta-analysis to synthesise bot...
Original Research | By Giacoppo D, Gargiulo G, Capodanno D et al.
STUDY QUESTION - What is the most safe and effective interventional treatment for coronary in-stent restenosis? METHODS - In a hierarchical Bayesian network meta-analysis, PubMed, Embase, Scopus, Cochrane Library, Web of Science, ScienceDirect, and major scientific websites were screened up to 10 August 2015. Randomised controlled trials of patients with any type of coronary in-stent restenosis (either o...