Original Research | By DA Jones, KS Rathod, S Koganti et al.
OBJECTIVES - This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). BACKGROUND - Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. ...
Clinical Trial | By Bourantas CV, Ramasamy A, Karagiannis A et al.
AIMS - To examine the efficacy of angiography derived endothelial shear stress (ESS) in predicting atherosclerotic disease progression. METHODS AND RESULTS - Thirty-five patients admitted with ST-elevation myocardial infarction that had three-vessel intravascular ultrasound (IVUS) immediately after revascularization and at 13 months follow-up were included. Three dimensional (3D) reconstruction of the no...
Clinical Trial | By Stone PH, Saito S, PREDICTION Investigators.
BACKGROUND - Atherosclerotic plaques progress in a highly individual manner. The purposes of the Prediction of Progression of Coronary Artery Disease and Clinical Outcome Using Vascular Profiling of Shear Stress and Wall Morphology (PREDICTION) Study were to determine the role of local hemodynamic and vascular characteristics in coronary plaque progression and to relate plaque changes to clinical events. ...
Stroke Rates Following Surgical Versus Percutaneous Coronary Revascularization
Original Research | By Head SJ, Milojevic M, Daemen J et al.
BACKGROUND - Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are used for coronary revascularization in patients with multivessel and left main coronary artery disease. Stroke is among the most feared complications of revascularization. Due to its infrequency, studies with large numbers of patients are required to detect differences in stroke rates between CABG and PCI. ...
Clinical Trial | By Gorter TM, Obokata M, Borlaug BA et al.
AIMS - Pulmonary hypertension (PH) and pulmonary vascular disease (PVD) are common and associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of PVD on the pathophysiology of exercise intolerance. METHODS AND RESULTS - Heart failure with preserved ejection fraction patients (n = 161) with elevated pulmonary capillary we...
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Clinical Trial | By Ridker PM, Everett BM, CANTOS Trial Group et al.
BACKGROUND - Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS - We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous m...
Inflammation: A New Target For CAD Treatment and Prevention
Clinical Trial | By Joner M, Koppara T, Prevention of PRESTIGE Investigators et al.
OBJECTIVES - The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography. BACKGROUND - In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation. METHODS - Angiography and intravascular optical coher...
BACKGROUND - Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. METHODS - Consecutive patients presenting with ST were prospectively enrolled in a registry by using a...
Characteristics of stent thrombosis in bifurcation lesions analysed by optical coherence tomography
Clinical Trial | By Bechiri MY, Souteyrand G, Lefèvre T et al.
AIMS - This work aimed to investigate a cohort of patients presenting with stent thrombosis (ST) explored by optical coherence tomography (OCT) to identify the underlying mechanical abnormalities in case of bifurcation lesions. METHODS AND RESULTS - The PESTO study was a prospective national registry involving 29 French catheterisation facilities. Patients with acute coronary syndromes were pr...