Clinical Trial | By Ahn JM, Roh JH, Park SJ et al.
BACKGROUND - In a previous randomized trial, we found that percutaneous coronary intervention (PCI) was not inferior to coronary artery bypass grafting (CABG) for the treatment of unprotected left main coronary artery stenosis at 1 year. OBJECTIVES - This study sought to determine the 5-year outcomes of PCI compared with CABG for the treatment of unprotected left main coronary artery stenosis. ...
Clinical Trial | By Yu CW, Yang JH, Gwon HC et al.
OBJECTIVES - This study investigated the impact of final kissing ballooning (FKB) after main vessel (MV) stenting on outcomes in patients with coronary bifurcation lesions after application of the 1-stent technique. BACKGROUND - Although FKB has been established as the standard method for bifurcation lesions treated with a 2-stent strategy, its efficacy in a 1-stent approach is highly controversial. ...
Clinical Trial | By Ferreira de Souza T, Quinaglia A C Silva T, Coelho-Filho OR et al.
OBJECTIVES - The goal of this study was to demonstrate that cardiac magnetic resonance could reveal anthracycline-induced early tissue remodeling and its relation to cardiac dysfunction and left ventricular (LV) atrophy. BACKGROUND - Serum biomarkers of cardiac dysfunction, although elevated after chemotherapy, lack specificity for the mechanism of myocardial tissue alterations. METHO...
Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation
Original Research | By Zhang JX, Qu XL, Chen SL et al.
Uncoupled endothelial nitric oxide synthase (eNOS) produces O2- instead of nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O2- production. Nevertheless, it is unclear whether autophagy plays a critical role in the regulation of eNOS uncoupling. Therefore, this study aimed to investigate the modulation of autophagy on eNOS uncoupling in...
Low shear stress induces endothelial reactive oxygen species via the AT1R/eNOS/NO pathway
Original Research | By Chao Y, Ye P, Chen SL et al.
Reactive oxygen species (ROS) contribute to many aspects of physiological and pathological cardiovascular processes. However, the underlying mechanism of ROS induction by low shear stress (LSS) remains unclear. Accumulating evidence has shown that the angiotensin II type 1 receptor (AT1R) is involved in inflammation, apoptosis, and ROS production. Our aim was to explore the role of AT1R in LSS-mediated ROS induction. We ex...
Original Research | By Gamou T, Sataka K,Yamagishi M et al.
OBJECTIVES - To investigate the impact of stent deformity induced by final kissing balloon technique (KBT) for coronary bifurcation lesions on in-stent restenosis (ISR). BACKGROUND - In experimental models, the detrimental effects of KBT have been clearly demonstrated, but few data exists regarding the impact of proximal stent deformity induced by KBT on clinical outcomes. ...
Guideline | By Task Force Members, Franz-Josef Neumann et al.
Original Research | By Andersson HB, Pedersen F, Engstrøm T et al.
AIMS - We aimed to study survival and causes of death in patients with ST-elevation acute coronary syndrome (STE-ACS) with and without obstructive coronary artery disease (CAD). METHODS AND RESULTS - We included 4793 consecutive patients with STE-ACS triaged for acute coronary angiography at a large cardiac invasive centre (2009-2014). Of these, 88% had obstructive CAD (stenosis ≥50%), 6% had ...
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
Original Research | By The ASCEND Study Collaborative Group.
BACKGROUND - Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. METHODS - We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive ...
Review Article | By Antithrombotic Trialists’ (ATT) Collaboration.