Recommandation Statement | By US Preventive Services Task Force
Screening for Atrial Fibrillation With ECG: USPSTF Recommendation
Clinical Trial | By K Hibi, K Kozuma, S Sonoda et al.
OBJECTIVES - The aim of this study was to evaluate the utility of distal protection during percutaneous coronary intervention (PCI) in patients with acute coronary syndromes at high risk for distal embolization. BACKGROUND - The results of previous clinical trials indicated that the routine use of distal protection in patients with ST-segment elevation myocardial infarction did not improve clinical outcomes. Howe...
Original Research | By Javier Escaned, Nicola Ryan, Hernán Mejía-Rentería
OBJECTIVES - The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND - Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the ...
Sex Differences in Adenosine-Free Coronary Pressure Indexes - A CONTRAST Substudy
Clinical Trial | By SV Shah, FM Zimmermann, NP Johnson et al.
OBJECTIVES - The goal of this study was to investigate sex differences in adenosine-free coronary pressure indexes. BACKGROUND - Several adenosine-free coronary pressure wire indexes have been proposed to assess the functional significance of coronary artery lesions; however, there is a theoretical concern that sex differences may affect diagnostic performance because of differences in resting flow and di...
Original Research | By D Nakamura, W Wijns, MJ Price et al.
OBJECTIVES - This study sought to compare conventional methodology (CM) with a newly described optical coherence tomography (OCT)-derived volumetric stent expansion analysis in terms of fractional flow reserve (FFR)-derived physiology and device-oriented composite endpoints (DoCE). BACKGROUND - The analysis of coronary stent expansion with intracoronary imaging has used CM that relies on the analysis o...
Oxygen therapy in ST-elevation myocardial infarction
Clinical Trial | By R Hofmann, N Witt, B Lagerqvist et al.
AIMS - To determine whether supplemental oxygen in patients with ST-elevation myocardial infarction (STEMI) impacts on procedure-related and clinical outcomes. METHODS AND RESULTS - The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial randomized patients with suspected myocardial infarction (MI) to receive oxygen at 6 L/min for 6–12 h o...
Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction
Original Research | By Y Wang, J Li, LX Jiang et al.
IMPORTANCE - Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify risk factors for recurrence have primarily focused on the period immediately following AMI admission. OBJECTIVES - To identify risk factors and develop and evaluate a risk model that predicts 1-year cardiovascular events after AMI. DESIGN, SETTI...
Original Research | By MJ Yang, L Song, L Wang et al.
BACKGROUND - Macrophages are highly plastic cells that play an important role in the pathogenesis of cardiovascular disease. OBJECTIVES - This study investigated the role of GATA3-positive macrophages in modulating cardiac function after myocardial infarction (MI) or in response to pressure overload hypertrophy. METHODS - Myeloid-specific GAT...
Clinical Trial | By KW Zhang, BS Finkelman, G Gulati et al.
OBJECTIVES - The objective of this study was to evaluate the changes in three-dimensional (3D) speckle-tracking echocardiography–derived measures of mechanics and their associations with systolic and diastolic dysfunction after anthracyclines. BACKGROUND - An improved understanding of the changes in 3D cardiac mechanics with anthracyclines may provide important mechanistic ins...