Original Research | By Johns CS, Wild JM, Rajaram S et al.
Purpose To assess interventricular septal (IVS) angle in the identification of combined pre- and postcapillary pulmonary hypertension (Cpc-PH) in patients with pulmonary hypertension (PH) due to left-sided heart disease. Materials and Methods In this retrospective study, consecutive, incident patients suspected of having PH underwent same-day right-sided heart catheterization (RHC) and MRI at a PH referral center between April 2012 and ...
Clinical Trial | By A Samman-Tahhan, JS Hedley, AA. McCue et al.
OBJECTIVES - This study sought to evaluate INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles for prognostic use among ambulatory non–inotrope-dependent patients with heart failure with reduced ejection fraction (HFrEF). BACKGROUND - Data for INTERMACS profiles and prognoses in ambulatory patients with HFrEF are limited. ...
Ambulatory Inotrope Infusions in Advanced Heart Failure - A Systematic Review and Meta-Analysis
Original Research | By T Nizamic, MH Murad, LA Allen et al.
OBJECTIVES - This study sought to systematically review the available evidence of risks and benefits of ambulatory intravenous inotrope therapy in advanced heart failure (HF). BACKGROUND - Ambulatory inotrope infusions are sometimes offered to patients with advanced Stage D HF; however, an understanding of the relative risks and benefits is lacking. METHODS - On August 7, 2016,...
Prognostic Value of the Residual SYNTAX Score After Functionally Complete Revascularization in ACS
BACKGROUND - The residual SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score (RSS) quantitatively assesses angiographic completeness of revascularization after percutaneous coronary intervention (PCI) and has been shown to be a predictor of events after angiography-guided PCI. In stable patients undergoing functionally complete revascularization with fractional flow reserve (FFR...
Clinical Trial | By Layland J, Oldroyd KG, FAMOUS–NSTEMI investigators.
AIM - We assessed the management and outcomes of non-ST segment elevation myocardial infarction (NSTEMI) patients randomly assigned to fractional flow reserve (FFR)-guided management or angiography-guided standard care. METHODS AND RESULTS - We conducted a prospective, multicentre, parallel group, 1 : 1 randomized, controlled trial in 350 NSTEMI patients with ≥1 coronary stenosis ≥30% of the lumen ...
Clinical Trial | By Iqbal J, Zhang YJ, Serruys PW et al.
BACKGROUND - There is a paucity of data on the use of optimal medical therapy (OMT) in patients with complex coronary artery disease undergoing revascularization with percutaneous coronary intervention or coronary artery bypass grafting (CABG) and its long-term prognostic significance. METHODS AND RESULTS - The Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (S...
Original Research | By K Mashayekhi, TG Nührenberg, A Toma et al.
OBJECTIVES - The aim of this study was to investigate whether percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) improves left ventricular function. BACKGROUND - The benefit of PCI in CTOs is still controversial. METHODS - Patients with CTOs who were candidates for PCI were eligible for the study and were randomized to PCI or no PCI ...
Original Research | By EK Oikonomou, M Marwan, MY Desai et al.
Original Research | By Stone GW, Généreux P, Harrington RA et al.
AIMS - In the CHAMPION PHOENIX trial, the potent, rapidly acting, intravenous platelet adenosine diphosphate receptor antagonist cangrelor reduced the 48-h incidence of major adverse cardiac events (MACE; death, myocardial infarction, stent thrombosis, or ischaemia-driven revascularization) compared with a loading dose of clopidogrel in patients undergoing percutaneous coronary intervention (PCI). We sought to determine whether...
Original Research | By Dobre D, Kjekshus J, Rossignol P et al.
OBJECTIVE - To assess the relationship between heart rate (HR), pulse pressure (PP), and their association with mortality in a population of high-risk patients following acute myocardial infarction (MI). METHODS - We performed an analysis in 22,398 patients included in "The High-Risk Myocardial Infarction Database Initiative", a database of clinical trials...