Original Research | By Chhatriwalla AK, Decker C, Gialde E et al.
BACKGROUND - Drug-eluting stents reduce the risk of restenosis in patients undergoing percutaneous coronary intervention, but their use necessitates prolonged dual antiplatelet therapy, which increases costs and bleeding risk, and which may delay elective surgeries. While >80% of patients in the United States receive drug-eluting stents, less than a third report that their physicians discussed options with them. ...
Original Research | By J Silvain, T Rakowski, B Lattuca et al.
BACKGROUND - In the ACCOAST (A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST Elevation Myocardial Infarction) trial, the prasugrel pre-treatment strategy versus placebo was associated with excess bleeding complications and no improved ischemic outcome in non–ST-segment elevation myocardial infarction (MI). Whether patients with the longest pre-treatment duration had an ischemic benefit is unknown. ...
PCI and CABG for Treating Stable Coronary Artery Disease
Review Article | By T Doenst, A Haverich, P Serruys et al.
Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are considered revascularization procedures, but only CABG can prolong life in stable coronary artery disease. Thus, PCI and CABG mechanisms may differ. Viability and/or ischemia detection to guide revascularization have been unable to accurately predict treatment effects of CABG or PCI, questioning a revascularization mechanism for ...
Original Research | By Salisbury AC, Karmpaliotis D, Grantham JA et al.
OBJECTIVES - The aim of this study was to describe the costs of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) and the association of complications during CTO PCI with costs and length of stay (LOS). BACKGROUND - CTO PCI generally requires more procedural resources and carries higher risk for complications than PCI of non-CTO vessels. The costs of CTO PCI usin...
Original Research | By Szijgyarto Z, Rampat R, Werner GS et al.
OBJECTIVES - The aim was to establish a contemporary scoring system to predict the outcome of chronic total occlusion coronary angioplasty. BACKGROUND - Interventional treatment of chronic total coronary occlusions (CTOs) is a developing subspecialty. Predictors of technical success or failure have been derived from datasets of modest size. A robust scoring tool could facilitate case selection and inform...
Clinical Trial | By Lee SW, Lee PH, Park SJ et al.
BACKGROUND - Procedural results for percutaneous coronary intervention (PCI) in coronary vessels with chronic total occlusion (CTO) have improved in recent years, and PCI strategies have moved toward more complete revascularization with more liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies and small clinical trials. METHODS - In this open-label...
Association of Cardiovascular Disease With Respiratory Disease
Original Research | By P Carter, J Lagan, C Fortune et al.
BACKGROUND- The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear. OBJECTIVES- This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evalu...
Association Between Functional Impairment and Medication Burden in Adults with Heart Failure
Original Research | By Goyal P, Bryan J, Kneifati-Hayek J et al.
OBJECTIVES - To determine whether the number of medications taken by adults with heart failure (HF) and impairment in activities of daily living (ADL)-a subpopulation in whom the risks of a high medication burden may outweigh the benefits-differs from the number taken by those without impairment in ADLs. DESIGN - Cross-sectional. SETTING - National Health...
Functional Impairment and Medication Burden in Adults With Heart Failure
Expert Opinion | By Ariela R. Orkaby, MD; Michael W. Rich, MD, FACC
RATIONALE FOR STUDY/BACKGROUND - Polypharmacy is most often defined as concurrent use of five or more medications,1-3 and is often present in older adults with chronic heart failure (CHF).4 Furthermore, many older adults with CHF have concomitant limitations in functional abilities,5 and polypharmacy is generally associated with a decline in functional status and worse outcomes overall.3 Moreover, guideline conc...
Original Research | By Bevan GH, Kalra A, Josephson RA, Al-Kindi SG