The Objective Physical Activity and Cardiovascular Disease Health in Older Women (OPACH) Study
Original Research | By J Bellettiere , MJ LaMonte , KR Evenson et al.
Original Research | By Xue X, Chen SL; MOODY trial investigators.
BACKGROUND - Differences in the predictors between ventricular septal rupture (VSR) and free wall rupture (FWR) have not been fully studied. Data on the prevalence and clinical outcome of heart rupture are limited. HYPOTHESIS - This study aimed to investigate heart rupture incidence and clinical results in patients with acute myocardial infarction (AMI). METHODS - Of 9265 AMI patients in ...
Primary Prevention of Heart Failure in Women
Research Correspondence | By MA Daubert, PS Douglas.
The incidence of heart failure (HF) is increasing, particularly among women, and constitutes a rapidly growing public health problem. The primary prevention of HF in women should involve targeted, sex-specific strategies to increase awareness, promote a heart healthy lifestyle, and improve treatments that optimally control the risk factors for HF with reduced ejection fraction and HF with preserved ejection fraction. Epidemiologic...
Is Cardiac Diastolic Dysfunction a Part of Post-Menopausal Syndrome?
Review Article | By P Z Maslov, JK Kim, E Argulian et al.
Post-menopausal women exhibit an exponential increase in the incidence of heart failure with preserved ejection fraction compared with men of the same age, which indicates a potential role of hormonal changes in subclinical and clinical diastolic dysfunction. This paper reviews the preclinical evidence that demonstrates the involvement of estrogen in many regulatory molecular pathways of cardiac diastolic function and the clini...
Review Article | By Beale AL, Meyer P, Kaye DM et al.
Consistent epidemiological data demonstrate that patients with heart failure with preserved ejection fraction (HFpEF) are more likely to be women than men. Exploring mechanisms behind this sex difference in heart failure epidemiology may enrich the understanding of underlying HFpEF pathophysiology and phenotypes, with the ultimate goal of identifying therapeutic approaches for the broader HFpEF population. In this review w...
Original Research | By AL Beale, S Nanayakkara, L Segan et al.
OBJECTIVES - This study sought to identify sex differences in central and peripheral factors that contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF) by using complementary invasive hemodynamic and echocardiographic approaches. BACKGROUND - Women are overrepresented among patients with HFpEF, and there are established sex differences in myocardial structure and function....
Review Article | By Montero D, Diaz-Canestro C.
BACKGROUND - Severe exercise intolerance (EI), demonstrated by impaired peak oxygen consumption, intrinsically characterizes heart failure with preserved ejection fraction (HFpEF). Controversy exists on the determinants of EI in patients with HFpEF according to case-control studies. The purpose of this study is to systematically review and clarify the main (Fick) determinants of EI in HFpEF. M...