Original Research | By DeFina LF, Radford NB, Barlow CE et al.
IMPORTANCE - Few data are available to guide clinical recommendations for individuals with high levels of physical activity in the presence of clinically significant coronary artery calcification (CAC). OBJECTIVE - To assess the association among high levels of physical activity, prevalent CAC, and subsequent mortality risk. DESIGN, SETTING, AND PARTICIPANTS ...
Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association
Expert Opinion | By Karlee K Hoffman, MD; Sir Raymond L. Benza, MD, FACC; Manreet Kanwar, MBBS, FACC
Pulmonary arterial hypertension (PAH) is a chronic disease of the pulmonary vasculature characterized by progressive narrowing of the pulmonary arteries, which in turn leads to increased pulmonary vascular resistance, right heart failure, and death.1 There has been a significant improvement in the available medical therapeutic options in this field that have impacted the short-term survival and morbidity in these patients.2 However, the medi...
Canadian SCAD Cohort Study: Shedding Light on SCAD From a United Front
Expert Opinion | By Calvin Ka Wing Tong, MD; Dr. Jacqueline W. L. Saw, MD, FACC
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI), particularly affecting young women. It is defined as a non-traumatic, non-iatrogenic, and non-atherosclerotic separation of the coronary arterial wall by intramural hematoma, resulting in a false lumen with or without intimal tear. Intramural hematoma can accumulate between any arterial layer (intima, media, or adventitia) an...
Original Research | By F Alqahtani, KM Ziada, V Badhwar et al.
BACKGROUND - Post-operative acute coronary ischemia is an uncommon complication of coronary artery bypass grafting (CABG). However, data on the incidence and outcomes of early coronary ischemia and in-hospital percutaneous coronary interventions (PCIs) after CABG are scarce. OBJECTIVES - The aim of this study was to assess the incidence, predictors, and outcomes of early (in-hospital) PCI following C...
Original Research | By van Rein N, Heide-Jørgensen U, Lijfering WM et al.
Original Research | By Lim CC, Hayes RB, Ahn J et al.
BACKGROUND - Recent experimental evidence suggests that nutritional supplementation can blunt adverse cardiopulmonary effects induced by acute air pollution exposure. However, whether usual individual dietary patterns can modify the association between long-term air pollution exposure and health outcomes have not been previously investigated. We assessed, in a large cohort with detailed diet information at the individual level, whether a Me...
Original Research | By Fracassi F, Niccoli G, Vetrugno V et al.
BACKGROUND - Patients with acute coronary syndrome (ACS) associated to high C-reactive protein (CRP) levels exhibit a higher risk of future acute ischemic events. Yet, the positive predictive value of CRP is too low to guide a specific treatment. Our study aims to identify a high-risk patient subset who might mostly benefit from anti-inflammatory treatment on the basis of the combination of optical coherence tomography ...
Original Research | By Farkouh ME, Domanski M, FREEDOM Follow-On study investigators.
BACKGROUND - The FREEDOM trial demonstrated that for patients with diabetes mellitus (DM) and multivessel coronary disease (MVD), coronary artery bypass grafting (CABG) is superior to percutaneous coronary intervention with drug-eluting stents (PCI-DES) in reducing the rate of major adverse cardiovascular and cerebrovascular events after a median follow-up of 3.8 years. It is not known, however, whether CABG con...