Consensus | By Writing Committee, SM Lilly, AJ Deshmukh et al.
Consensus | By F Burzotta; JF Lassen; T Lefèvre et al.
The 15th European Bifurcation Club (EBC) meeting was held in Barcelona in October 2019 and it facilitated a renewed consensus on coronary bifurcation lesions (CBL) and unprotected left main (LM) percutaneous interventions. Bifurcation stenting techniques continue to be refined, developed and tested. It remains evident that provisional approach with optional side-branch treatment utilising T, T and sma...
Clinical Trial | By RV Jeger, A Farah, BASKET-SMALL 2 Investigators et al.
BACKGROUND - In the treatment of de-novo coronary small vessel disease, drug-coated balloons (DCBs) are non-inferior to drug-eluting stents (DESs) regarding clinical outcome up to 12 months, but data beyond 1 year is sparse. We aimed to test the long-term efficacy and safety of DCBs regarding clinical endpoints in an all-comer population undergoing percutaneous coronary intervention. METHODS - In this...
Colchicine Reduces Cardiovascular Events in Chronic Coronary Disease
Clinical Trial | By SM Nidorf, ATL Fiolet, the LoDoCo2 Trial Investigators.
BACKGROUND - Evidence from a recent trial has shown that the antiinflammatory effects of colchicine reduce the risk of cardiovascular events in patients with recent myocardial infarction, but evidence of such a risk reduction in patients with chronic coronary disease is limited. METHODS - In a randomized, controlled, double-blind trial, we assigned patients with chronic coronary disease to receive 0.5 mg of colc...
Original Research | By E Ajufo, CR Ayers, R Vigen et al.
IMPORTANCE - Higher coronary artery calcium (CAC) identifies individuals at increased atherosclerotic cardiovascular disease (ASCVD) risk. Whether it can also identify individuals likely to derive net benefit from aspirin therapy is unclear. OBJECTIVE - To examine the association between CAC, bleeding, and ASCVD and explore the net estimated effect of aspirin at different CAC thresholds. D...
Original Research | By D Zanetti , S Gustafsson, E Ingelsson et al.
BACKGROUND - Circulating biomarkers have been previously associated with atherosclerosis related risk factors, but the nature of these associations is incompletely understood. METHODS - We performed multivariable-adjusted regressions and two-sample Mendelian randomization (MR) analyses to assess observational and causal associations of 27 circulating biomarkers with 7 cardiovascular traits in up to 451...
Dilated cardiomyopathy: so many cardiomyopathies!
Expert Opinion | By G Sinagra, PM Elliott, M Merlo et al.
The current definition of dilated cardiomyopathy (DCM) is relatively simple; namely, a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient to explain the dysfunction.1 In the last decades, the prognosis of patients with DCM has improved significantly with survival free from death and heart transpla...
Original Research | By ME Farkouh , LC Godoy, V Fuster et al.