Clinical Trial | By Généreux P, Giustino G, Redfors B et al.
BACKGROUND - Risk stratification after percutaneous coronary intervention (PCI) is mainly based on demographics and clinical presentation (stable coronary artery disease [CAD] vs. acute coronary syndromes [ACS]). We investigated the impact of PCI extent and complexity on 2-year clinical outcomes after successful implantation of drug-eluting stents (DES) and whether this effect is influenced by clinical presentation and/or high pla...
Operator Experience and Outcomes After Left Main Percutaneous Coronary Intervention
Review Article | By Kanmanthareddy A, Anugula D, Kar B.
PURPOSE OF REVIEW - This review was performed with the goal of summarizing the role of operator experience in the treatment of severe left main stenosis by percutaneous intervention techniques. RECENT FINDINGS - The Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL) trial demonstrated that percutaneous coronary intervention ...
Clinical Trial | By Fuernau G, Beck J, Thiele H et al.
BACKGROUND - Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock following acute myocardial infarction. The objective of this study was to investigate hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicating acute myocardial infarction. METHODS - Patients (n=40) with cardiogenic shock undergoing primary percutaneous coro...
Applications of left ventricular strain measurements to patients undergoing chemotherapy
Review Article | By Clasen SC, Scherrer-Crosbie M.
PURPOSE OF REVIEW - We aim to summarize the utility of strain in monitoring the effects of cancer therapy-related cardiotoxicity (CTRC) on the development of left ventricular (LV) dysfunction. RECENT FINDINGS - Serial assessment of cardiac function at baseline and during treatment is recommended in patients undergoing cancer treatment. Historically, the use of left ventricular ejection fraction (LVE...
Cardiovascular effects of radiation therapy
Review Article | By Armanious MA, Mohammadi H, Khodor S et al.
Radiation therapy (RT) plays a prominent role in the treatment of many cancers. With increasing use of RT and high overall survival rates, the risks associated with RT must be carefully considered. Of these risks, the cardiovascular and autonomic toxicities have been of significant concern. In fact, cardiovascular disease is the leading cause of nonmalignancy-related death in cancer survivors. The manifestations of radiation induced cardiac inju...
Review Article | By Boi A, Jamthikar AD, Suri JS et al.
PURPOSE OF REVIEW - Atherosclerotic plaque deposition within the coronary vessel wall leads to arterial stenosis and severe catastrophic events over time. Identification of these atherosclerotic plaque components is essential to pre-estimate the risk of cardiovascular disease (CVD) and stratify them as a high or low risk. The characterization and quantification of coronary plaque components are not only vital but also a challenging task...
Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators - The RAID Trial
Clinical Trial | By W Zareba, JP Daubert, CA Beck et al.
BACKGROUND - Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs). OBJECTIVES - This study aimed to determine whether ranolazine administration decreases the likelihood of VT, VF, or death in patients with an ICD. METHODS - This was double-blind, placebo-controlled clinical t...
Clinical Trial | By Kaier TE, Twerenbold R, Marber M et al.
BACKGROUND - Cardiac myosin-binding protein C (cMyC) is a cardiac-restricted protein that is more abundant than cardiac troponins (cTn) and is released more rapidly after acute myocardial infarction (AMI). We evaluated cMyC as an adjunct or alternative to cTn in the early diagnosis of AMI. METHODS - Unselected patients (N=1954) presenting to the emergency department with symptoms suggestive of AM...
Letter | By TE Kaier , R Twerenbold , C Puelacher et al.
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Letter | By XW Jiang , HW Tian and SB Qiao et al.
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