Clinical Trial | By Henriques JP, Hoebers LP, EXPLORE Trial Investigators.
Review Article | By Iannaccone M, D'ascenzo F, Piazza F et al.
INTRODUCTION - The optimal management of patients with coronary chronic total occlusions (CTO) remains controversial. This meta-analysis aims to compare percutaneous coronary intervention of CTO (CTO-PCI) versus optimal medical therapy (OMT) in CTO patients. METHODS - A literature search with highly specific terms was conducted using MEDLINE, EMBASE, and Web of Science to identify m...
Original Research | By Ahn JH, Yang JH, Choi SH et al.
INTRODUCTION AND OBJECTIVES - Limited data are available on the clinical outcomes of optimal medical therapy (OMT) compared with revascularization by percutaneous coronary intervention (PCI) in patients with chronic total coronary occlusion (CTO) of the proximal or middle left anterior descending artery (pmLAD). Therefore, the objective of this study was to compare the long-term outcomes of patients with pmL...
Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT
Original Research | By DL Bhatt, G Steg, and on behalf of the REDUCE-IT Investigators.
North American Expert Review of Rotational Atherectomy
Original Research | By Sharma SK, Tomey MI, Teirstein PS et al.
Rotational atherectomy (RA) is an established tool in interventional cardiology for treatment of calcified coronary lesions. Over 3 decades of clinical experience and research, techniques have matured and outcomes have improved. Heterogeneity exists, however, in RA utilization and technique. We assembled a group of experienced RA operators and device experts to summarize and critique key elements of contemporary RA technique...
Major trials in coronary intervention from 2018
Review Article | By Patel A, Marah N, Balan P et al.
PURPOSE OF REVIEW - This article will review the major clinical trials related to coronary intervention that were released in 2018. Areas of interest include lesion assessment, novel stent design, acute coronary syndromes (ACSs), and major breakthroughs in chronic total occlusion interventions. RECENT FINDINGS - The benefit of intracoronary imaging and hemodynamic assessment was demonstrated by...
Ticagrelor versus Clopidogrel in Patients with STEMI Treated with Fibrinolytic Therapy: TREAT Trial
Original Research | By Berwanger O, Lopes RD, Moia DDF et al.
BACKGROUND - The efficacy of ticagrelor in the long-term post ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remains uncertain. OBJECTIVES - To evaluate the efficacy of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. METHODS - We conducted an international, multicenter, randomized, open-label ...
Clinical Trial | By Dewilde WJ, Oirbans T, WOEST study investigators.
BACKGROUND - If percutaneous coronary intervention (PCI) is required in patients taking oral anticoagulants, antiplatelet therapy with aspirin and clopidogrel is indicated, but such triple therapy increases the risk of serious bleeding. We investigated the safety and efficacy of clopidogrel alone compared with clopidogrel plus aspirin. METHODS - We did an open-label, multicentre, randomised, controlled trial in ...
Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI
Clinical Trial | By Gibson CM, Mehran R, Bode C et al.
BACKGROUND - In patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) with placement of stents, standard anticoagulation with a vitamin K antagonist plus dual antiplatelet therapy (DAPT) with a P2Y12 inhibitor and aspirin reduces the risk of thrombosis and stroke but increases the risk of bleeding. The effectiveness and safety of anticoagulation with rivaroxaban plus either one or two antiplatelet agent...